Platelet Function ASA (Verify Now)


Sunquest Code:ASA  
Epic Code:LAB5337Epic Name:Platelet Function ASA
Synonyms:Aspirin; VerifyNow ASA; Platelet Function ASA; Platelet Function Aspirin
Methodology:Turbidmetric-based optical detection
CPT Code:----------CPTCODES HERE----------
Turnaround Time:Performed and reported 24 hours/day.
Special Instructions:
This test requires a special tube be used that can only be filled to one amount for proper testing results. Test must be performed within 4 hours of collection. Specimen must be hand delivered; do not send via Pneumatic Tube System (PTS). This test is intended for patients on anti-platelet medication and is not intended for patients with genetic abnormalities.

Patients who have been treated with glycoprotein IIb/IIIa inhibitors should not be tested until the platelet function has recovered. This time period is approximately 48 hours after discontinuation of eptifibatide and tirofiban, and 14 days after discontinuation of abciximab. Other platelet drugs such as P2Y12 inhibitors (e.g. clopidogrel), NSAIDs, etc. may also affect the results of this assay. The test should not be performed in patients with low platelet counts (less than 100 x 109/L) or in patients with inherited platelet dysfunction.  


Collection Instructions

Specimen:Blood
Optimal Volume:2 mL
Collection Instructions:Whole blood samples must be collected using a 21 gauge or larger needle and immediately transferred into a special blue Greiner Bio. Only one test may be assayed per tube. If ordering both ASA and P2Y12 an additional specimen is required.
Causes for Rejection:Specimen that is clotted, hemolyzed, greater than 4 hours old, sent via PTS, or stored in the refrigerator or freezer prior to testing. Specimen cannot be used if it has been centrifuged. Overfilled tube.


Processing and Shipping

Specimen Processing:Whole blood. Do not process.
Shipping Instructions:Hand-deliver. Must arrive for testing within 4 hours of collection at room temperature.
Test Performed at or Referral Lab Coagulation  (UMMC-West Bank, UMMC-East Bank, Fairview Southdale - FSH)


Interpretive

Reference Range:

Aspirin Assay

Result

Therapeutic range

Less than 550 ARU

Non-therapeutic range (less inhibition by aspirin)

Greater than or equal to 550 ARU

 

Test results are reported in Aspirin Reaction Units (ARU) which indicate the amount of thromboxane A2-mediated activation of glycoprotein IIb/IIIa receptors involved in platelet aggregation. ARU is calculated as a function of the rate and extent of platelet aggregation. The lower the value, the more inhibition is present, consistent with a response to aspirin.

 

Therapeutic Range:Therapeutic Range (for aspirin): Less than 550 ARU
Use:Aids in the detection of platelet inhibition due to aspirin therapy.


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