Immunoglobulin Total Light Chains, Urine


Sunquest Code:TLCU  
Epic Code:LAB5595Epic Name:Total Light Chain UR
Synonyms:Urine Light Chains; Light Chains, Kappa and Lambda; Immunoglobulin Light Chains
Methodology:Nephelometry
CPT Code:83883
Turnaround Time:Specimens are sent to reference laboratory Mon-Fri; results are reported within 3-7 days.
Compliance:

This test was developed and its performance characteristics determined by Laboratory Medicine and Pathology, Mayo Clinic. This test has not been cleared by the U.S. Food and Drug Administration.



Collection Instructions

Specimen:Urine, 24 hour collection or random collection
Optimal Volume:Submit entire volume; analysis requires 0.5 mL
Container:3 L plastic jug (Plastic leakproof container, sterile)
Collection Instructions:Refrigerate during collection.


Processing and Shipping

Specimen Processing:Mix collection well before aliquot is taken. Aliquot 1 mL, 0.5 mL minimum. Store in refrigerator.
Shipping Instructions:Ship at refrigerated temperature.
Test Performed at or Referral Lab Lab Sendouts  (Mayo)
Referral Lab number:TLCU


Interpretive

Reference Range:Kappa total light chain: <0.9 mg/dL Lambda total light chain: <0.7 mg/dL Kappa/lambda ratio: 0.7-6.2
Use:A kappa/lambda (K/L) ratio of >6.2 suggests the presence of monoclonal kappa light chains. A K/L ratio of <0.7 suggests the presence of monoclonal lambda light chains. In 24 hour specimens, a >25% increase in concentration suggests progression or relapse; a >25% decrease suggests treatment response. Increased kappa and/or lambda light chains may be seen in benign (polyclonal) and neoplastic (monoclonal) disorders.


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