Red Blood Cell (RBC) Enzyme Evaluation


Sunquest Code:EEEVP  
Epic Code:LAB5610Epic Name:RBC Enzyme Evaluation
Methodology:Kinetic Spectrophotometry (KS)
CPT Code:82657, 82955, 84087, 84220
Test Includes:Erythrocyte Enzyme Interpretation, G-6-PD, QN, RBC, Pyruvate Kinase, RBC, Glucose Phosphate Isomerase, B, and Hexokinase, B.
Turnaround Time:Specimens are sent to reference laboratory Mon-Fri; results are reported within 2-13 days.
Compliance:

This test was developed and its performance characteristics determined by Laboratory Medicine and Pathology, Mayo Clinic. This test has not been cleared by the U.S. Food and Drug Administration.



Collection Instructions

Specimen:Whole Blood
Optimal Volume:12 mL
Minimum\Peds Volume:5 mL
Causes for Rejection:Gross hemolysis


Processing and Shipping

Specimen Processing:Whole blood; do not process. Send sample in the original container.
Shipping Instructions:Ship at refrigerated temperature.
Test Performed at or Referral Lab Lab Sendouts  (Mayo)
Referral Lab number:EEEVP


Interpretive

Reference Range:By report.
Use:All enzyme defects, including erythrocyte enzyme errors, are inherited; some are sex-linked and located on the X chromosome. Some family members have no hematologic abnormalities, while others have a hemolytic anemia. For a number of red blood cell enzyme detects (e.g., deficiencies of hexokinase, glucosephosphate isomerase, pyruvate kinase), the sole clinical manifestation is hemolytic anemia. Glucose-6-phosphate dehydrogenase deficiency is the most common metabolic error of the red cell and presents with acute hemolytic anemia in response to oxidant stress (e.g., drugs, acute infections, fava bean ingestion). This is a consultative evaluation looking at red cell enzyme defects as the cause for early red cell destruction.


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