Porphyrins and Porphobilinogen, Urine

Sunquest Code:PORPOR  
Epic Code:LAB6041Epic Name:Porphyrins and Porphobilinogen, Urine
Methodology:High performance liquid chromography/ Ion exchange chromatography/Spectrophotometry
Turnaround Time:Specimens are sent to reference laboratory Mon-Sat; results are reported within 2-4 days.
Special Instructions:Total volume and collection time interval is required.

This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

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Urine Collection Procedure

Collection Instructions

Specimen:Urine, timed or random collection
Optimal Volume:Submit entire collection; analysis requires 4 mL
Container:3 L plastic jug (Plastic leakproof container, sterile)
Collection Instructions:Refrigerate during 24 hour collection.
Causes for Rejection:Not protected from light; stored at room temperature. Body fluids other than urine.

Processing and Shipping

Specimen Processing:Aliquot 8 mL, 4 mL minimum. Protect from light. Store in freezer. Accepted up to 4 days after collection if refrigerated and light protected. Record total volume and collection time interval on transport tube.
Shipping Instructions:Ship on dry ice.
Test Performed at or Referral Lab Lab Sendouts  (ARUP)
Referral Lab number:2002181


Reference Range:


0-4 µmol/mol crt

Heptacarboxylate Porphyrin

0-2 µmol/mol crt

Coproporphyrin I

0-6 µmol/mol crt

Coproporphyrin III

0-14 µmol/mol crt

Porphobilinogen, Urine

0.0-8.8 µmol/

Porphobilinogen, Urine (24-hour)

0.0-11.0 µmol/d*

*Results are normalized to creatinine concentration and reported as a ratio of amounts (micromoles of porphyrin/moles of creatinine.)


Use:Urine porphyrins are useful for the evaluation of cutaneous photosensitivity to exclude porphyria cutanea tarda (PCT). Urine porphobilinogen (PBG) is useful for the evaluation of neurologic and/or psychiatric symptoms to exclude acute porphyrias such as acute intermittent porphyria (AIP).

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