Aquaporin-4 Receptor Antibody, IgG by IFA with Reflex to Titer

Sunquest Code:NMOA4G  
Epic Code:LAB6883Epic Name:Neuromyelitis Optica AQP4 IGG with reflex blood
Synonyms:AQP; AQP4; NMO; Neuromyelitis Optica
Methodology:Semi-quantitative indirect fluorescent antibody
Turnaround Time:Specimens are sent to reference laboratory Mon-Sat; results are reported within 1-8 days.

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been approved or cleared by the US Food and Drug Administration (FDA). The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Collection Instructions

Optimal Volume:2 mL
Minimum\Peds Volume:0.5 mL
Container:Red or gold (gel) (Red (no gel))
Causes for Rejection:Contaminated specimens.

Processing and Shipping

Specimen Processing:Separate serum from cells ASAP. Centrifuge and aliquot 1 mL, 0.15 mL minimum. Store in refrigerator.
Shipping Instructions:Ship at refrigerated temperature.
Stability:Stability: 48 hours at room temperature; 2 weeks refrigerated; 1 year frozen.
Test Performed at or Referral Lab Lab Sendouts  (ARUP)
Referral Lab number:2013320


Reference Range:Aquaporin-4 Receptor Antibody IgG by IFA with Reflex to Titer, Serum: Less than 1:10   
Use:Diagnosis of neuromyelitis optica (NMO) requires the presence of longitudinally extensive acute myelitis (lesions extending over 3 or more vertebral segments) and optic neuritis. Approximately 75 percent of patients with NMO express antibodies to the aquaporin-4 (AQP4) receptor. While the absence of AQP4 receptor antibodies does not rule out a diagnosis of NMO, presence of this antibody is diagnostic for NMO.

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