Proinsulin, Intact

Sunquest Code:PROINS  
Epic Code:LAB5978Epic Name:Proinsulin
Methodology:Chemiluminescent immunoassay
Turnaround Time:Specimens are sent to reference laboratory Mon-Sat; results are reported within 1-6 days.
Special Instructions:Do not use to diagnose diabetes mellitus.

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been approved or cleared by the US Food and Drug Administration (FDA). The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Collection Instructions

Optimal Volume:2 mL
Minimum\Peds Volume:0.6 mL
Container:Red or gold (gel) (Purple (EDTA), Red (no gel))
Patient Preparation:Patient must fast for 12-15 hours prior to collection.
Causes for Rejection:Gross hemolysis

Processing and Shipping

Specimen Processing:Centrifuge and aliquot within 2 hours of collection 1 mL, 0.2 mL minimum. CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered. Store in freezer.
Shipping Instructions:Ship frozen on dry ice.
Stability:After separation from cells: 48 hours refrigerated; 2 months frozen.
Test Performed at or Referral Lab Lab Sendouts  (ARUP)
Referral Lab number:70112


Reference Range:

0-17 y

Not established

18 y and older

Less than or equal to 8.0 pmol/L



Use:Aids in the detection of insulinoma. Do not use to diagnose diabetes mellitus.

Fasting intact proinsulin values above the reference interval indicate a possible insulin secreting pancreatic tumor (insulinoma) in patients with hypoglycemia. Fasting intact proinsulin values range from 3 to 50 pmol/L in patients with untreated type 2 diabetes.

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