LDL Subclasses


Sunquest Code:LDLSUB  
Epic Code:LAB5984Epic Name:LDL Subclasses
Methodology:Electrophoresis
CPT Code:83701, 82465
Turnaround Time:Specimens are sent to reference laboratory Mon-Sat; results are reported within 1-8 days.


Collection Instructions

Specimen:Blood
Optimal Volume:2 mL
Minimum\Peds Volume:0.6 mL
Container:Red (no gel) (Purple (EDTA), Red or gold (gel))
Patient Preparation:12 hour patient fasting is preferred.
Causes for Rejection:Heparinized plasma. Specimens from patients receiving heparin.


Processing and Shipping

Specimen Processing:Centrifuge and aliquot within 2 hours of collection 1 mL, 0.2 mL minimum. Store refrigerated.
Shipping Instructions:Ship at refrigerated temperature.
Test Performed at or Referral Lab Lab Sendouts  (ARUP)
Referral Lab number:50021


Interpretive

Reference Range:

 

Recommended protocol:

·          Infants >2000 g: Collect newborn screen at 24-48 hours of age. Collect on “white cards” only.

·          Infants ≤2000 g: Follow a three stop process to collect at 24-48 hours of age, 14 days of age and 30 days of age. Collect on “yellow cards” or comment when sent to MDH as to the time of collection and age. Use the infant’s birth weight (not current weight) on the follow-up specimens. If infant is discharged before the 14 or 30 day screens, collect a specimen on the day of discharge. Reviewing the results of multiple screens will provide a more accurate risk assessment for the infant. This reflexive rescreening protocol is likely to reduce both false positive and false negative results.

 

Collect prior to 24 hours:

·          if infant is discharged or transferred to a different hospital prior to 24 hours.

·          if infant requires blood transfusion.

·          if infant requires large saline infusion.

·          if infant requires surgery, ECMO, ECLS or another major procedure.

·          if infant is unlikely to survive the first 24 hours of life. Results from the screening tests may contribute to an understanding of the newborn’s condition or provide important information to the parents that could benefit future children.

 

Collect addition sample if initial collection performed prior to 24 hours:

·          if infant is greater than 2000 grams, collect at 24-48 hours of age.

·          if infant is less than or equal to 2000 grams, collect at 14 and 30 days of age. May also collect at 24-48 hours of age per physician order.

·          If infant is transfused and a prior specimen was collected at <24 hours of age, collect additional sample at 24-48 hours of age.

 

Collect additional sample:

·          if infant is transfused and a prior specimen was not collected, collect additional samples at 24-48 hours of age and at 90 days after the last transfusion.

·          If infant is >2000 grams, is transfused, and a pre-transfusion specimen was collected at <24 hours of age, collect additional samples at 24-48 hours of age and at 90 days after the last transfusion.

·          if infant never received an initial screen or initial screen cannot be verified. Collect as soon as possible.

·          if MDH Newborn Screening Program requests a repeat specimen. Collect as soon as possible.

 

Use:Differentiates LDL particles with respect to size to identify individuals with phenotype A (large LDL particles) or B (small LDL particles); considered as a non-traditional CVD risk marker.


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