Insulin Like Growth Factor 1 (IGF1), Pediatric

Sunquest Code:IGF1Q  
Epic Code:LAB6350Epic Name:Insulin Like Growth Factor 1 (IGF-1) Pediatric
Synonyms:LC/MS; Insulin-Like Growth Factor
Methodology:Liquid chromatography/Mass spectrometry (LC/MS)
Turnaround Time:Specimens are sent to reference laboratory Mon-Fri; results are reported within 2-5 days.

This test was developed and its performance characteristics determined by Quest Diagnostics Nichols Institute, San Juan Capistrano. Performance characteristics refer to the analytical performance of this test.

Collection Instructions

Optimal Volume:1.5 mL
Minimum\Peds Volume:0.8 mL
Container:See Collection Instructions (West Bank: Special red no gel BD tube that has green "IGF1Q to Quest" sticker, obtained from the lab, Red (no gel))
Collection Instructions:UMMC-West Bank Only: Collect in the special red, no gel tubes labeled with the green "IGF1A to Quest" stickers.
Causes for Rejection:Room temperature specimens, grossly hemolyzed, lipemic or icteric specimens. Specimens received in a glass tube.

Processing and Shipping

Specimen Processing:Allow blood to clot for 10-15 minutes at room temperature. Centrifuge and aliquot 0.5 mL, 0.3 mL minimum. Store in frozen.
Shipping Instructions:Ship frozen.
Stability:Stability: 2 days at room temperature; 5 days refrigerated; 28 days frozen (preferred).
Test Performed at or Referral Lab Lab Sendouts  (Quest Diagnostics)
Referral Lab number:16293


Reference Range:By report.
Use:Insulin-like growth factor I (IGF-I or somatomedin C), a protein involved in stimulating somatic growth, is regulated principally by growth hormone (GH) and nutritional intake. IGF-I is transported in serum by several proteins; this helps maintain relatively high IGF-I plasma levels and minimizes fluctuations in serum IGF-I concentrations. Measuring IGF-I is useful in several growth-related disorders. Dwarfism caused by deficiency of growth hormone (hypopituitarism) results in decreased serum levels of IGF-I, while acromegaly (growth hormone excess) results in elevated levels of IGF-I. IGF-I measurements are also helpful in assessing nutritional status; levels are reduced in undernutrition and restored with a proper diet.

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