Mannose Binding Lectin


Sunquest Code:MANLEC  
Epic Code:LAB6679Epic Name:Mannose Binding Lectin
Methodology:ELISA
CPT Code:83520
Turnaround Time:Specimens are sent to reference laboratory Mon-Sat; results are reported within 1-8 days.
Compliance:

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been approved or cleared by the US Food and Drug Administration (FDA). The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.



Collection Instructions

Specimen:Blood
Optimal Volume:2 mL
Minimum\Peds Volume:0.6 mL
Container:Red or gold (gel) (Green (lithium heparin, gel), Red (no gel))


Processing and Shipping

Specimen Processing:Centrifuge and aliquot within 2 hours of collection 1 mL, 0.2 mL minimum.
Shipping Instructions:Ship on dry ice.
Test Performed at or Referral Lab Lab Sendouts  (ARUP)
Referral Lab number:51692


Interpretive

Reference Range:Greater than 50 ng/mL.
Use:Mannose-binding protein is a component of the innate or natural immune system which binds to mannose residues on a variety of different microorganisms. When bound, this lectin will trigger the complement pathway resulting in opsonization. Mannose-binding protein is also an acute phase reactant produced by the liver. Patients who have abnormal levels of mannose-binding protein may have recurrent significant infections in the absence of abnormalities in the four major arms of the immune system. Abnormal mannose-binding protein concentrations have been found in patients with infectious disorders such as tuberculosis, hepatitis B and in autoimmune disorders including recurrent spontaneous abortion and systemic erythematosus.


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