Heparin-Dependent Platelet Antibody (SRA) Unfractionated


Sunquest Code:HDPA  
Epic Code:LAB6539Epic Name:Heparin Dependent PLT Aby SRA
Synonyms:Serotonin Release Assay; SRA; SRA-Porcine Heparin
Methodology:Serotonin release assay
CPT Code:86022
Turnaround Time:Specimens are sent to reference laboratory Mon-Fri; results are reported within 1-3 days.


Collection Instructions

Specimen:Blood
Optimal Volume:10 mL
Minimum\Peds Volume:2.2 mL
Container:Red (gel) (Red (no gel))


Processing and Shipping

Specimen Processing:Centrifuge and aliquot 5 mL, 1 mL minimum. Store in refrigerator.
Shipping Instructions:Ship at refrigerated temperature or on dry ice.
Test Performed at or Referral Lab Lab Sendouts  (Blood Center of Wisconsin)
Referral Lab number:5508


Interpretive

Reference Range:A positive result requires greater than or equal to 20% release of serotonin with low dose heparin AND less than 20% release in the presence of a high concentration of heparin. Results are interpreted as negative, borderline positive or positive.
Limitations:The presence of "non-drug" antibodies reactive with platelets (e.g., HLA Class I, autoantibodies, platelet-specific antibodies) in the patient's serum can induce heparin independent release of serotonin in the SRA. Testing with Lovenox® (Enoxaparin) versus unfractionated heparin has not been validated as a useful guide to clinical management.


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