Tripeptidyl Peptidase 1 (TPP1) and Palmitoyl-Protein Thioesterase 1 (PPT1), Leukocytes - LG5896


Sunquest Code:MMMISC  
Epic Code:LAB4909Epic Name:Send Outs Misc Test
Synonyms:TPP1 and PPT1, WBC
Methodology:Fluorometric
CPT Code:82657
Turnaround Time:Specimens are sent to reference laboratory Mon-Thur before 1300; results are reported within 8-15 days.
Special Instructions:

A signed informed consent in the patient's medical record is required; the consent should not be sent to the laboratory. See Associated Links. Specimen must arrive refrigerated within 144 hours of draw to be stabilized. Draw specimen Mon-Thur only and do not send the day before a holiday. Specimen should be drawn and packaged as close to shipping time as possible.

 

Specimen must arrive refrigerated within 144 hours of draw to be stabilized. Draw specimen Monday through Thursday only and not the day before a holiday. Specimen should be drawn and packaged as close to shipping time as possible.

 

Compliance:

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

Associated Links:

Genetic Testing Consent Form



Collection Instructions

Specimen:Blood
Optimal Volume:6 mL
Minimum\Peds Volume:5 mL
Causes for Rejection:Gross hemolysis.


Processing and Shipping

Specimen Processing:Do not process. Store in refrigerator.
Shipping Instructions:Ship at refrigerated temperature (preferred).
Test Performed at or Referral Lab Lab Sendouts  (Mayo Medical Laboratories)
Referral Lab number:TPPTL


Interpretive

Reference Range:

TPP1

85-326 nmol/hour/mg protein

PPT1

20-93 nmol/hour/mg protein

 

 

Use:Tripeptidyl peptidase 1 (TPP1) and palmitoyl-protein thioesterase 1 (PPT1) enzyme activity below 5 nmol/hour/mg of protein are highly suggestive of late-infantile and infantile neuronal ceroid lipofuscinoses, respectively.


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