Copper, Liver Tissue


Sunquest Code:CPLVTS  
Epic Code:LAB6764Epic Name:Copper, Liver Tissue
Methodology:Inductively coupled plasma/Mass spectrometry
Turnaround Time:Specimens are sent to reference laboratory Mon-Sat; results are reported within 2-6 days.
Compliance:

This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.



Collection Instructions

Specimen:Liver tissue
Optimal Volume:2 cm (collected with a 18-gauge needle)
Minimum\Peds Volume:1 cm (collected with an 18 gauge needle)
Container:Metal-free container, Tissue
Collection Instructions:Tissue can be fresh, paraffin-embedded or dried. Also acceptable: Formalin-fixed. Specimens other than paraffin-embedded should be stored and transported in a metal-free container, such as a royal blue (no additive).
Causes for Rejection:Specimens less than 0.25 mg (dry weight). Paraffin blocks that have been processed with Hollandes or other copper-containing stain.


Processing and Shipping

Specimen Processing:Store in refrigerator.
Shipping Instructions:Ship at refrigerated temperature.
Stability:Stability: Paraffin block, preserved (formalin) or dried: Indefinitely at room temperature, refrigerated or frozen. Fresh tissue: 1 week refrigerated; indefinitely frozen.
Test Performed at or Referral Lab Lab Sendouts  (ARUP)
Referral Lab number:20694


Interpretive

Reference Range:15-55 ug/g of tissue
Use:Hepatic copper concentrations approach or exceed 250 ug/g in untreated Wilson disease. Elevated hepatic copper is also seen with chronic biliary obstruction and cholestatic conditions Results inconsistent with other findings may reflect heterogeneity in hepatic copper distribution.


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