Cortisol, Salivary


Sunquest Code:SACORT  
Epic Code:LAB6614Epic Name:Cortisol Saliva
Synonyms:Salivary Cortisol
Methodology:Enzyme immunoassay
CPT Code:82530
Turnaround Time:Specimens are sent to reference laboratory Mon-Sat; results are reported within 1-4 days.


Collection Instructions

Specimen:Saliva
Optimal Volume:1 mL
Minimum\Peds Volume:0.3 mL
Collection Instructions:Use Salivette collection device. Swab must be completely saturated to ensure sufficient volume for testing. Transfer saturated swab to plain (non-citric acid) cotton Salivette collection device (ARUP Supply #52056). Record time of collection on the test request form and on Salivette transport container.
Patient Preparation:
Do not collect specimen within 60 minutes after eating a meal, within 12 hours after consuming alcohol, immediately after brushing teeth, after any activity that may cause gums to bleed. Rinse mouth thoroughly with water 10 minutes before specimen collection. Recommended collection time is between 11:00 pm and 1:00 am.
Causes for Rejection:Specimens not collected using the Salivette collection device. Sodium azide preservative. Specimens with pH values greater than 9.0 or less than 3.5 must be recollected. Specimens visibly contaminated with blood, cellular debris, food particles or mucus. Do not collect specimen within 60 minutes after eating a meal, within 12 hours after consuming alcohol, immediately after brushing teeth or after any activity that may cause gums to bleed.
Contraindications:Bleeding in the mouth.


Processing and Shipping

Specimen Processing:Do not process. Store in refrigerator.
Shipping Instructions:Ship at refrigerated temperature.
Test Performed at or Referral Lab Lab Sendouts  (ARUP)
Referral Lab number:81117


Interpretive

Reference Range:

By report.

 

Limitations:Bovine hormones can cross-react with anti-cortisol antibodies and cause false results. Acidic or high sugar foods can compromise assay performance by lowering sample pH and influence bacterial growth. The presence of blood in the sample can cause false high results.
Use:

Rule out Cushing’s Syndrome. Screen for thymic and bronchial carcinoid tumors.

For a collection at 2300 hr, the normal cortisol concentration is less than 0.112 µg/dL. Patients with Cushing’s Syndrome have concentrations of 0.112 µg/dL or greater.

 



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