N-Methylhistamine, Urine

Sunquest Code:NMHIN  
Epic Code:LAB6500Epic Name:N-Methylhistamine Urine
Methodology:Liquid chromatography/Tandem mass spectrometry (LC-MS/MS); Enzymatic colorimetric assay
CPT Code:82542
Turnaround Time:Specimens are sent to reference laboratory Mon-Fri; results are reported within 3-7 days.
Special Instructions:Please indicate volume and duration of collection on 24 hour specimens.

This test was developed and its performance characteristics determined by Laboratory Medicine and Pathology, Mayo Clinic. This test has not been cleared by the U.S. Food and Drug Administration.

Collection Instructions

Specimen:Urine, timed or random
Optimal Volume:Submit entire collection; analysis requires 3 mL
Minimum\Peds Volume:3 mL
Container:Plastic leakproof container, sterile (3 L plastic jug)
Collection Instructions:Store specimen refrigerated during collection.

Processing and Shipping

Specimen Processing:Aliquot 5 mL, 3 mL minimum. Store frozen.
Shipping Instructions:Ship frozen.
Test Performed at or Referral Lab Lab Sendouts  (Mayo Medical Laboratories)
Referral Lab number:NMHIN


Reference Range:

0-5 y

120-510 mcg/g creatinine

6-16 y

70-330 mcg/g creatinine

Greater than16 y

30-200 mcg/g creatinine



Use:Screening for and monitoring of mastocytosis and disorders of systemic mast-cell activation, such as anaphylaxis and other forms of severe systemic allergic reactions. Monitoring therapeutic progress in conditions that are associated with secondary, localized, low-grade persistent, mast-cell proliferation and activation such as interstitial cystitis.

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