Prostaglandin D2 (PGD2) to Mayo


Sunquest Code:FPGD2  
Epic Code:LAB6503Epic Name:Prostaglandin (PGD2)
Methodology:Radioimmunoassay (RIA)
CPT Code:84150
Turnaround Time:Specimens are sent to reference laboratory Mon-Fri; results are reported within 5-9 days.
Special Instructions:Specimen processing instructions are intended for patients with possible mast cell activation. Please see the Mayo website for further information and alternate processing instructions. (See Associated Links).
Compliance:

This test uses a reagent or kit labeled by the manufacturer as Research Use Only. Its performance characteristics were determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

Associated Links:

Mayo Medical Laboratories



Collection Instructions

Specimen:Blood
Optimal Volume:6 mL
Minimum\Peds Volume:2.2 mL
Container:Purple (EDTA) on ICE (Purple (EDTA), Red (no gel), Red or gold (gel))
Collection Instructions:Place pre-chilled tubes between two cold gel packs or on wet ice during and after collection. Keep samples refrigerated at all times. UMMC-East: Walk samples immediately to Specimen Management for processing.
Patient Preparation:Patient should not be on aspirin, indomethacin or anti-inflammatory medications (if possible) for at least 48 hours prior to collection of specimen.
Causes for Rejection:Room temperature or refrigerated specimens.


Processing and Shipping

Specimen Processing:Centrifuge for 8 minutes at 4 degrees C. Aliquot 3 mL, 1 mL minimum and freeze immediately.
Shipping Instructions:Ship on dry ice.
Test Performed at or Referral Lab Lab Sendouts  (Mayo Medical Laboratories)
Referral Lab number:FPGD2


Interpretive

Reference Range:35-115 pg/mL. No pediatric reference ranges are available for this test.
Use:Prostaglandins are fatty acids derived from arachidonic acid metabolism. They are closely related to the Thromboxanes and Leukotrienes. Prostaglandin D2 is derived mainly from Prostaglandin H2, and is metabolized to Dihydroketo Prostaglandin D2. Prostaglandin D2 is excreted directly into the urine. The sites of highest Prostaglandin D2 activity are the brain, spinal cord, intestines, and stomach. Prostaglandin D2 is the major Prostaglandin produced by uterine tissue. Prostaglandin D2 is a potent bronchoconstrictor, neuromodulator and anti-antithrombin agent. It also stimulates the secretion of Pancreatic Glucagon. Prostaglandin D2 has been found to have anti-metastatic effect on many malignant tumor cells. Prostaglandin D2 production and circulating levels are drastically suppressed by aspirin and Indomethacin.


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