Prostaglandin D2 (PGD2) Serum or Plasma


Sunquest Code:PGD2A  
Epic Code:LAB8139Epic Name:Prostaglandin D2 (PGD2) Serum or Plasma
Methodology:Radioimmunoassay (RIA)
CPT Code:84150
Turnaround Time:Specimens are sent to reference laboratory Mon-Sat; results are reported within 10-17 days.


Collection Instructions

Specimen:Blood
Optimal Volume:6 mL
Minimum\Peds Volume:2.2 mL
Container:Purple (EDTA) (Red (no gel))
Patient Preparation:Patient should not be on aspirin, indomethacin or anti-inflammatory medications (if possible) for at least 48 hours prior to collection of specimen.
Causes for Rejection:Room temperature or refrigerated specimens.


Processing and Shipping

Specimen Processing:Within 10 minutes of collection, centrifuge and aliquot 3 mL, 1 mL minimum and freeze immediately. CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.
Shipping Instructions:Ship on dry ice.
Test Performed at or Referral Lab Lab Sendouts  (ARUP)
Referral Lab number:3000219


Interpretive

Reference Range:35-115 pg/mL. No pediatric reference ranges are available for this test.
Use:Prostaglandins are fatty acids derived from arachidonic acid metabolism. They are closely related to the Thromboxanes and Leukotrienes. Prostaglandin D2 is derived mainly from Prostaglandin H2, and is metabolized to Dihydroketo Prostaglandin D2. Prostaglandin D2 is excreted directly into the urine. The sites of highest Prostaglandin D2 activity are the brain, spinal cord, intestines, and stomach. Prostaglandin D2 is the major Prostaglandin produced by uterine tissue. Prostaglandin D2 is a potent bronchoconstrictor, neuromodulator and anti-antithrombin agent. It also stimulates the secretion of Pancreatic Glucagon. Prostaglandin D2 has been found to have anti-metastatic effect on many malignant tumor cells. Prostaglandin D2 production and circulating levels are drastically suppressed by aspirin and Indomethacin.


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