Arsenic, Fractionated, Urine


Sunquest Code:ARSF  
Epic Code:LAB4586Epic Name:Arsenic Frationated Urine
Methodology:Inductively coupled plasma/mass spectrometry/High performance liquid chromatography
Turnaround Time:Specimens are sent to reference laboratory Mon-Sat; results are reported within 1-10 days.
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Urine Collection Procedure



Collection Instructions

Specimen:Urine, 24 hour or random collection
Optimal Volume:Submit entire collection; analysis requires 2 mL
Container:3 L plastic jug (Plastic leakproof container, sterile)
Collection Instructions:Specimen should be refrigerated during collection. ARUP studies indicate that refrigeration of urine alone, during and after collection, preserves specimens adequately if tested within 14 days of collection.
Causes for Rejection:Urine collected within 48 hours after administration of gadolinium (Gd) containing contrast media (may occur with MRI studies). Acid preserved urine. Specimens contaminated with blood or fecal material. Samples not aliquoted into ARUP metal-free plastic vials.


Processing and Shipping

Specimen Processing:Mix collection well before aliquot is taken. Aliquot 8 mL, 2 mL minimum into 2 ARUP blue top metal free plastic vials. Regular aliquot tubes will be rejected. Record total volume and collection duration on transport tube and request form. Store in refrigerator.
Shipping Instructions:Ship at refrigerated temperature.
Stability:1 week at room temperature; 2 weeks refrigerated; 1 year frozen.
Test Performed at or Referral Lab Lab Sendouts  (ARUP)
Referral Lab number:20734


Interpretive

Reference Range:By report. The ACGIH Biological Exposure Index for the sum of inorganic and methylated forms (species) of arsenic is 35 ug/L. Inorganic forms of arsenic are most toxic. Methylated forms arise primarily from metabolism of inorganic forms, but may also come from dietary sources and are of moderate toxic potential. The organic forms of arsenic are considered nontoxic and arise primarily from food. The sum of the inorganic, methylated and organic forms of arsenic may be lower than the total arsenic level.
Use:Diagnose acute or chronic arsenic poisoning. Urine is preferred to blood levels for detection of chronic exposure. Urine arsenic levels 4 hours following seafood ingestion have been reported to reach 200-1700 ug/L, much of which may represent relatively nontoxic organic forms, such as arsenobetaine. To differentiate between organic and the more toxic inorganic forms, an arsenic speciation test is recommended and can be performed with the existing specimen at the client's request.


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