Leukotriene E4, Urine


Sunquest Code:LTE4  
Epic Code:LAB6543Epic Name:Leukotriene E4 Urine
Methodology:Liquid chromatrography/ Tandem mass spectrometry (LC/MS/MS); Enzymatic colorimetric assay
CPT Code:83789
Turnaround Time:Specimens are sent to reference laboratory Mon-Fri; results are reported within 2-6 days.
Special Instructions:Please indicate volume and duration of collection on 24 hour specimens. UMMC-East: For Dr. Afrin's patients, the sample must be collected in a pre-chilled container and remain on ice or refrigerated at all times.
Compliance:

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.



Collection Instructions

Specimen:Urine, timed or random
Optimal Volume:Submit entire collection; analysis requires 1 mL
Minimum\Peds Volume:1 mL
Container:Plastic leakproof container, sterile (Plastic leakproof container, sterile, 3 L plastic jug)
Collection Instructions:Store specimen refrigerated during collection.


Processing and Shipping

Specimen Processing:Aliquot 4 mL, 1 mL minimum. Store frozen.
Shipping Instructions:Ship frozen.
Test Performed at or Referral Lab Lab Sendouts  (Mayo Medical Laboratories)
Referral Lab number:LTE4


Interpretive

Use:Elevated urinary leukotriene E4 (LTE4) concentrations >104 pg/mg creatinine are consistent with the diagnosis of systemic mast cell disease when combined with clinical signs and symptoms. Pharmacological treatment with 5-lipoxygenase inhibitors or leukotriene receptor antagonists has been shown to decrease production of LTE4.


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