Leukotriene E4, Urine


Sunquest Code:LTE4  
Epic Code:LAB6543Epic Name:Leukotriene E4 Urine
Methodology:Liquid chromatography/Tandem mass spectrometry (LC/MS/MS); Enzymatic colorimetric assay
Turnaround Time:Specimens are sent to reference laboratory Mon-Fri; results are reported within 2-6 days.
Compliance:

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.



Collection Instructions

Specimen:Urine, timed or random
Optimal Volume:Submit entire collection; analysis requires 1 mL
Minimum\Peds Volume:1 mL
Container:Plastic leakproof container, sterile (3 L plastic jug)
Collection Instructions:Store specimen refrigerated during collection.


Processing and Shipping

Specimen Processing:Aliquot 4 mL, 1 mL minimum. Store frozen.
Shipping Instructions:Ship frozen.
Stability:Stability: Refrigerated - 7 days; frozen - 30 days.
Test Performed at or Referral Lab Lab Sendouts  (Mayo Medical Laboratories)
Referral Lab number:LTE4


Interpretive

Use:Elevated urinary leukotriene E4 (LTE4) concentrations >104 pg/mg creatinine are consistent with the diagnosis of systemic mast cell disease when combined with clinical signs and symptoms. Pharmacological treatment with 5-lipoxygenase inhibitors or leukotriene receptor antagonists has been shown to decrease production of LTE4.


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