Hepatitis C Virus High Resolution Genotyping


Sunquest Code:HEPCHI  
Epic Code:LAB9465Epic Name:Hepatitis C High Res Genotype
Synonyms:HCV Genotyping
Methodology:Polymerase chain reaction (PCR) /Sequencing
CPT Code:87902
Turnaround Time:Specimens are sent to reference laboratory Mon-Sat; results are reported within 5-8 days.
Special Instructions:Do not order prior to molecular confirmation of positive hepatitis C virus (HCV) screen. See Hepatitis C Screen with Reflex to HCV RNA Quantitation and HCV Genotype (HCVSR). Order before initiating HCV therapy to aid in prognosis and therapy selection when a higher level of subtype resolution is required (i.e. non 6a/b vs. type 1 and type 1a vs. 1b.
Compliance:

This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Associated Links:

Hep C Screening with Reflex Cascade Algorithm



Collection Instructions

Specimen:Blood
Optimal Volume:4 mL
Minimum\Peds Volume:1.2 mL
Container:Purple (EDTA) (Red (no gel), Red or gold (gel))
Causes for Rejection:Heparinized specimens.


Processing and Shipping

Specimen Processing:Centrifuge and aliquot 2 mL, 0.5 mL minimum serum or plasma within 6 hours of collection..
Shipping Instructions:Ship on dry ice.
Test Performed at or Referral Lab Lab Sendouts  (ARUP)
Referral Lab number:2006898


Interpretive

Reference Range:By report
Use:Isolates of hepatitis C virus are grouped into six major genotypes (1-6). The genotypes are subtyped according to sequence characteristics. Sequencing both the Core and NS5B regions allows for subtyping of all confirmed and most provisional genotypes. Including differentiation of 1a from 1b and typing of genotype 6. This test may be unsuccessful if the HCV RNA viral load is less than log 5.0 or 100,000 IU/mL.


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