Voltage-Gated Potassium Channel (VGKC) Antibody


Sunquest Code:VGKCAB  
Epic Code:LAB6678Epic Name:Voltage-gated Potassium Channel Antibody
Methodology:Radioimmunoassay
CPT Code:----------CPTCODES HERE----------
Turnaround Time:Specimens are sent to reference laboratory Mon-Sat. Tests are performed on Wed; results are reported within 1-8 days.
Compliance:

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been approved or cleared by the US Food and Drug Administration (FDA). The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.



Collection Instructions

Specimen:Blood
Optimal Volume:8 mL
Minimum\Peds Volume:1.2 mL
Container:Red (no gel) (Red or gold (gel))
Causes for Rejection:Plasma. Grossly lipemic or icteric specimens.


Processing and Shipping

Specimen Processing:Separate serum from cells within 1 hour of collection. Centrifuge and aliquot 4 mL, 0.5 mL minimum. Store in refrigerator.
Shipping Instructions:Ship at refrigerated temperature.
Test Performed at or Referral Lab Lab Sendouts  (ARUP)
Referral Lab number:2004890


Interpretive

Reference Range:

Negative

31 pmol/L or less

Indeterminate

32-87 pmol/L

Positive

88 pmol/L or greater

 

 

Use:Voltage-Gated Potassium Channel (VGKC) antibodies are associated with neuromuscular weakness as found in neuromyotomia (also know as Isaacs Syndrome) and Morvan Syndrome. VGKC antibodies are also associated with paraneoplastic neurological syndromes and limbic encephalitis; however, VGKC antibody-associated limbic encephalitis may be associated with antibodies to leucine-rich, glioma-inactivated 1 protein (Lgi1) or contactin-associated protein-2 (Caspr-2) instead of potassium channel antigens.


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