Urticaria Induced Basophil Activation

Sunquest Code:UIBASA  
Epic Code:LAB6817Epic Name:Urticaria Basophil Activation
Methodology:Semi-quantitative flow cytometry
Turnaround Time:Specimens are sent to reference laboratory Mon-Sat; results are reported within 7-10 days.

This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Collection Instructions

Optimal Volume:2 mL
Minimum\Peds Volume:1.2 mL
Container:Red (no gel)
Causes for Rejection:Specimens other than serum. Contaminated, grossly hemolyzed or lipemic specimens.

Processing and Shipping

Specimen Processing:Centrifuge and aliquot 1 mL, 0.5 mL minimum within 2 hours of collection. Store frozen.
Shipping Instructions:Ship at frozen temperature. CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.
Stability:After separation from cells: 30 minutes at room temperature; unacceptable refrigerated; 1 year frozen.
Test Performed at or Referral Lab Lab Sendouts  (ARUP)
Referral Lab number:2005416


Reference Range:

27 percent or less

Negative – No basophil activation detected.

28-38 percent

Indeterminate – Borderline basophil activation detected.

39 percent or greater

Positive – Basophil activation detected.



Use:Determine whether CD203c is upregulated in suspected chronic urticaria if urticaria is felt to be due to autoimmune antibodies to the basophil IgE receptor or to IgE.

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