11-Deoxycortisol, Pediatric


Sunquest Code:11DCTP  
Epic Code:LAB6874Epic Name:11-Deoxycortisol, Pediatric
Synonyms:11-deoxy-17-hydroxycorticosterone; Cortodoxone; Deoxycortisol
Methodology:Liquid chromatography/Tandem mass spectrometry
CPT Code:82634
Turnaround Time:Specimens are sent to reference laboratory Mon-Fri; results are reported within 2-9 days.


Collection Instructions

Specimen:Blood
Optimal Volume:2 mL
Minimum\Peds Volume:0.7 mL
Container:Red (no gel) (Green (sodium heparin, no gel), Purple (EDTA))
Collection Instructions:An early morning specimen is preferred.
Causes for Rejection:Collection in a gel top tube.


Processing and Shipping

Specimen Processing:Centrifuge and aliquot 1 mL, 0.25 mL minimum. Store frozen
Shipping Instructions:Ship on dry ice.
Test Performed at or Referral Lab Lab Sendouts  (Quest)
Referral Lab number:30543x


Interpretive

Reference Range:

 

Pediatric

1-12 mo

10-200 ng/dL

1-4 y

7-210 ng/dL

5-9 y

≤ 122 ng/dL

10-13 y

≤ 245 ng/dL

14-17 y

≤ 302 ng/dL

 

Infant

Premature (31-35 wk)

≤ 235 ng/dL

Term

≤ 170 ng/dL

 

Tanner Stages

II-III Male

11-150 ng/dL

II-III Female

15-130ng/dL

IV-V Male

14-120 ng/dL

IV-V Female

17-120 ng/dL

 

 

Use:11-Deoxycortisol (Compound S) is useful in diagnosing patients with 11-beta-hydroxylase deficiency (second leading cause of congenital adrenal hyperplasia) and primary (adrenal failure) or secondary (hypothalamic-pituitary ACTH deficiency) adrenal insufficiency.


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