Drug Detection Panel, Umbilical Cord, Qualitative


Sunquest Code:CRDDS  
Epic Code:LAB6902Epic Name:Drug Detection Panel, Umbilical Cord Tissue
Synonyms:Cord Drug Screen
Methodology:Liquid chromatography/Tandem mass spectrometry/Enzyme-linked immunosorbent assay
Test Includes:See Associated Link.
Turnaround Time:Specimens are sent to reference laboratory Mon-Sat; results are reported within 1-3 days.
Compliance:

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the U.S. Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.
Associated Links:

ARUP Test Table Meconium and Umbilical Cord, Add'l ARUP Test Info, Umbilical Cord Segment Collection for Drug Testing


Collection Instructions

Specimen:See Collection Instructions.
Optimal Volume:Over 8 inches in length of cord tissue
Minimum\Peds Volume:8 inches in length of cord tissue is sufficient for both drug detection panel and marijuana metabolite testing. If also requested, ethyl glucuronide requires 2 additional inches. All three tests can be submitted on a single 8 inch cord sample.
Container:Plastic leakproof container sterile with red tamper resistant tape
Collection Instructions:
  1. Cut a 8 inch section of the umbilical cord.
  2. Drain and discard any blood by sliding the cord through your pinched finger and thumb.
  3. Rinse the exterior of the cord segment with normal saline or water.
  4. Pat the cord dry and transfer specimen to the sterile, leakproof container; apply red tamper-resistant tape over the lid.
   
Causes for Rejection:Cords soaking in blood or other fluid. Formalin fixed. Tissue that is obviously decomposed.


Processing and Shipping

Specimen Processing:Store frozen.
Shipping Instructions:Ship at frozen temperature.
Stability:1 week at room temperature; 3 weeks refrigerated; 1 year frozen.
Test Performed at or Referral Lab Lab Sendouts  (ARUP)
Referral Lab number:2006621


Interpretive

Reference Range:Not detected. Drugs Covered and Range of Cutoff Concentrations:
Drugs/Drug Classes Cutoff Concentrations
(ng/g)		 Drugs/Drug Classes Cutoff Concentrations
(ng/g)
Buprenorphine 1 Amphetamine 5
Norbuprenorphine 0.5 Benzoylecgonine 0.5
    m-OH-Benzoylecgonine 1
Codeine 0.5 Cocaethylene 1
Dihydrocodeine 1 Cocaine 0.5
Fentanyl 0.5 MDMA (Ecstasy) 5
Hydrocodone 0.5 Methamphetamine 5
Norhydrocodone 1 Phentermine 8
Hydromorphone 0.5 Alprazolam 0.5
Meperidine 2 Alpha-OH-Alprazolam 0.5
Methadone 2 Butalbital 25
Methadone metabolite 1 Clonazepam 1
6-Acetylmorphine 1 7-Aminoclonazepam 1
Morphine 0.5 Diazepam 1
Naloxone 1 Lorazepam 5
Oxycodone 0.5 Midazolam 1
Noroxycodone 1 Alpha-OH-Midazolam 2
Oxymorphone 0.5 Nordiazepam 1
Noroxymorphone 0.5 Oxazepam 2
Propoxyphene 1 Phenobarbital 75
Tapentadol 2 Tamazepam 1
Tramadol 2 Zolpidem 0.5
N-desmethyltramadol 2 Phencyclidine (PCP) 1
O-desmethyltramadol 2 Gabapentin 10
 
Use:Detection of drugs in umbilical cord tissue is intended to reflect maternal drug use during approximately the last trimester of a full-term pregnancy. The pattern and frequency of drug(s) used by the mother cannot be determined by this test. A negative result does not exclude the possibility that a mother used drugs during pregnancy. Detection of drugs in umbilical cord tissue depends on extent of maternal drug use, as well as drug stability, unique characteristics of drug deposition in umbilical cord tissue, and the performance of the analytical method. Drugs administered during labor and delivery may be detected. Detection of drugs in umbilical cord tissue does not insinuate impairment and may not affect outcomes for the infant. Interpretive questions should be directed to the laboratory. Glucuronide metabolites are indicated as-G. For medical purposes only; not valid for forensic use unless testing was performed within Chain of Custody process.


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