Androstenedione - For adults and children 7 years and older


Sunquest Code:ANDROS  
Epic Code:LAB511Epic Name:Androstenedione
Order Instructions:For children 6 years and under, cancel ANDROS and order ANDROP
Methodology:High performance liquid chromatography, Tandem mass spectrometry
Turnaround Time:Specimens are sent to reference laboratory Mon-Sat; results are reported in 1-4 days.
Special Instructions:Recently administered radioisotopes will interfere with this test, causing spurious results. Specimen should be collected between 6:00-10:00 am.
Compliance:

This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.



Collection Instructions

Specimen:Blood
Optimal Volume:2.0 mL
Minimum\Peds Volume:0.8 mL
Container:Red (no gel) (Green (lithium heparin, gel), Green (sodium heparin, no gel), Red or gold (gel))


Processing and Shipping

Specimen Processing:Centrifuge and aliquot 1 mL, 0.3 mL minimum.
Shipping Instructions:Ship on dry ice.
Stability:Stability: After separation from cells: 24 hours at room temperature; 1 week refrigerated; 6 months frozen.
Test Performed at or Referral Lab Lab Sendouts  (ARUP)
Referral Lab number:2001638


Interpretive

Reference Range:
Age Female
ng/mL
Male,
ng/mL
6-7 y 0.02-0.28 0.01-0.29
8-9 y 0.04-0.42 0.03-0.30
10-11 y 0.09-1.23 0.07-0.39
12-13y 0.24-1.73 0.10-0.64
14-15 y 0.39-2.00 0.18-0.94
0.9416-17 y 0.35-2.12 0.30-1.13
18-39 y 0.26-2.14 0.33-1.34
40 y and older 0.13-0.82 0.23-0.89
Premenopausal 0.26-2.14  
Postmenopausal 0.13-0.82  
Tanner Stage I 0.05-0.51 0.04-0.32
Tanner Stage II 0.15-1.37 0.08-0.48
Tanner Stage III 0.37-2.24 0.14-0.87
Tanner Stage IV-V 0.35-2.05 0.27-1.07
   
Use:The primary clinical use of AD levels is evaluation of hirsutism (abnormal hair growth) in which it is elevated in 60% of the cases. AD levels may also be elevated polycystic ovarian disease, congenital adrenal hyperplasia, and tumors of the adrenals or gonads. AD is not helpful in separating adrenal from gonadal causes of excess androgen secretion. Serum AD concentrations exhibit diurnal variation. Highest values occur at about 7:00 a.m., with lowest levels around 4:00 p.m., a magnitude of change of at least two. Levels also vary with the phase of the menstrual cycle. As the follicle matures and ovulation occurs, there is a twofold increase in AD levels that is maintained throughout the luteal phase.


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