Polymyositis and Dermatomyositis Panel


Sunquest Code:PDMYOP  
Epic Code:LAB6957Epic Name:Polymyositis and Dermatomyositis Panel
Methodology:Immunopreceipitation, Multiplex bead assay; Immunoblot
CPT Code:86235, 83516 x11
Test Includes:Jo-1 Antibody, IgG; Mi-2 (nuclear helicase protein) Antibody; PL-7 (threonyl-tRNA synthetase) Antibody; PL-12 (alanyl-tRNA synthetase ) Antibody; P155/140 Antibody; EJ (glycyl-tRNA synthetase) Antibody; SRP (Signal Recognition Particle) Antibody; OJ (isoleucyl-tRNA synthetase) Antibody; SAE1 (SUMO activating enzyme) Antibody; MDAS (CADM-140) Antibody; NXP-2 (Nuclear matrix protein-2) Antibody; TIF1-gamma (TIF1-y) Antibody
Turnaround Time:Specimens are sent to reference laboratory Mon-Sat; results are reported within 7-15 days.
Compliance:

This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.



Collection Instructions

Specimen:Blood
Optimal Volume:2 mL
Minimum\Peds Volume:1.2 mL
Container:Red or gold (gel) (Red (no gel))
Causes for Rejection:Hemolyzed, hyperlipemic, icteric, heat-treated or contaminated specimens.


Processing and Shipping

Specimen Processing:Centrifuge and aliquot within 2 hours of collection, 1 mL, 0.5 mL minimum. Store in refrigerator.
Shipping Instructions:Ship at refrigerated temperature.
Test Performed at or Referral Lab Lab Sendouts  (ARUP)
Referral Lab number:2013992


Interpretive

Reference Range:

Jo-1 Antibody

29 AU/mL or less:  Negative

30-40 AU/mL:  Equivocal

41 AU/mL:  or greater Positive

PL-7 (threonyl-tRNA synthetase) Antibody IgG

Negative

Mi-2 (nuclear helicase protein) Antibody

Negative

PL-12 (alanyl-tRNA synthetase ) Antibody

Negative

P155/140 Antibody;

Negative

EJ (glycyl-tRNA synthetase) Antibody

Negative

SRP (Signal Recognition Particle) Antibody

Negative

OJ (isoleucyl-tRNA synthetase) Antibody

Negative

SAE1 (SUMO activating enzyme) Antibody

Negative

MDAS (CADM-140) Antibody

Negative

NXP-2 (Nuclear matrix protein-2) Antibody

Negative

TIF1-gamma (TIF1-y) Antibody

Negative

 

 

Use:Evaluation of patients with progressive proximal muscle weakness and/or cutaneous manifestations suggestive of dermatomyositis and/or associated connective tissue disease.


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