Polymyositis and Dermatomyositis Panel

Sunquest Code:PDMYOP  
Epic Code:LAB6957Epic Name:Polymyositis and Dermatomyositis Panel
Methodology:Immunopreceipitation, Multiplex bead assay; Immunoblot
CPT Code:86235, 83516 x11
Test Includes:Jo-1 Antibody, IgG; Mi-2 (nuclear helicase protein) Antibody; PL-7 (threonyl-tRNA synthetase) Antibody; PL-12 (alanyl-tRNA synthetase ) Antibody; P155/140 Antibody; EJ (glycyl-tRNA synthetase) Antibody; SRP (Signal Recognition Particle) Antibody; OJ (isoleucyl-tRNA synthetase) Antibody; SAE1 (SUMO activating enzyme) Antibody; MDAS (CADM-140) Antibody; NXP-2 (Nuclear matrix protein-2) Antibody; TIF1-gamma (TIF1-y) Antibody
Turnaround Time:Specimens are sent to reference laboratory Mon-Sat; results are reported within 7-15 days.

This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Collection Instructions

Optimal Volume:4 mL
Minimum\Peds Volume:2.2 mL
Container:Red or gold (gel) (Red (no gel))
Causes for Rejection:Hemolyzed, hyperlipemic, icteric, heat-treated or contaminated specimens.

Processing and Shipping

Specimen Processing:Centrifuge and aliquot two 1 mL aliquots, two 0.5 mL aliquots minimum, within 2 hours of collection. Store in refrigerator.
Shipping Instructions:Ship at refrigerated temperature.
Test Performed at or Referral Lab Lab Sendouts  (ARUP)
Referral Lab number:2013992


Reference Range:

Jo-1 Antibody

29 AU/mL or less:  Negative

30-40 AU/mL:  Equivocal

41 AU/mL:  or greater Positive

PL-7 (threonyl-tRNA synthetase) Antibody IgG


Mi-2 (nuclear helicase protein) Antibody


PL-12 (alanyl-tRNA synthetase ) Antibody


P155/140 Antibody;


EJ (glycyl-tRNA synthetase) Antibody


SRP (Signal Recognition Particle) Antibody


OJ (isoleucyl-tRNA synthetase) Antibody


SAE1 (SUMO activating enzyme) Antibody


MDAS (CADM-140) Antibody


NXP-2 (Nuclear matrix protein-2) Antibody


TIF1-gamma (TIF1-y) Antibody




Use:Evaluation of patients with progressive proximal muscle weakness and/or cutaneous manifestations suggestive of dermatomyositis and/or associated connective tissue disease.

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