Dermatomyositis and Polymyositis Panel

Sunquest Code:PDMYOP  
Epic Code:LAB6957Epic Name:Polymyositis and Dermatomyositis Panel
Methodology:Immunopreceipitation, Multiplex bead assay; Immunoblot
Test Includes:Jo-1 Antibody, IgG; Mi-2 (nuclear helicase protein) Antibody; PL-7 (threonyl-tRNA synthetase) Antibody; PL-12 (alanyl-tRNA synthetase ) Antibody; P155/140 Antibody; EJ (glycyl-tRNA synthetase) Antibody; SRP (Signal Recognition Particle) Antibody; OJ (isoleucyl-tRNA synthetase) Antibody; SAE1 (SUMO activating enzyme) Antibody; MDA-5 (CADM-140) Antibody; NXP-2 (Nuclear matrix protein-2) Antibody; TIF1-gamma (TIF1-y) Antibody
Turnaround Time:Specimens are sent to reference laboratory Mon-Sat; results are reported within 7-18 days.

This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Collection Instructions

Optimal Volume:4 mL
Minimum\Peds Volume:2.2 mL
Container:Red or gold (gel) (Red (no gel))
Causes for Rejection:Hemolyzed, hyperlipemic, icteric, heat-treated or contaminated specimens.

Processing and Shipping

Specimen Processing:Centrifuge and aliquot two 1 mL aliquots, two 0.5 mL aliquots minimum, within 2 hours of collection. Store in refrigerator.
Shipping Instructions:Ship at refrigerated temperature.
Stability:48 hours at room temperature; 2 weeks refrigerated and 1 year frozen.
Test Performed at or Referral Lab Lab Sendouts  (ARUP)
Referral Lab number:3001783


Reference Range:
Jo-1 Antibody 29 AU/mL or less: Negative
30-40 AU/mL: Equivocal
41 AU/mL or greater: Positive
PL-7 (threonyl-tRNA
synthetase) Antibody, IgG
Mi-2 (nuclear helicase
protein) Antibody
PL-12 (alanyl-tRNA
synthetase) Antibody
P155/140 Antibody Negative
EJ (glycyl-tRNA
synthetase) Antibody
SRP (Signal Recognition
Particle) Antibody
OJ (isoleucyl-tRNA
synthetase) Antibody
SAE1 (SUMO activating
enzyme) Antibody
MDA-5 (CADM-140)
NXP-2 (Nuclear matrix
protein-2) Antibody
TIF1 - gamma (TIF1-γ)
Use:Evaluation of patients with progressive proximal muscle weakness and/or cutaneous manifestations suggestive of dermatomyositis and/or associated connective tissue disease.

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