Angiotensin Converting Enzyme, Serum


Sunquest Code:A1CE  
Epic Code:LAB179Epic Name:Angiotensin Converting Enzyme
Synonyms:ACE; Gaucher's Disease
Methodology:Enzymatic
CPT Code:82164
Turnaround Time:Specimens are sent to reference laboratory Mon-Sat; results are reported within 1 day.


Collection Instructions

Specimen:Blood
Optimal Volume:2 mL
Minimum\Peds Volume:1.2 mL
Container:Red or gold (gel) (Red (no gel))
Causes for Rejection:Collected in EDTA or heparin plasma; hemolyzed specimens.
Contraindications:Recently administered radioisotopes will interfere with this test, causing spurious results.


Processing and Shipping

Specimen Processing:Separate serum from cells within 2 hours of collection. Centrifuge and aliquot 1 mL, 0.5 mL minimum. Store in refrigerator.
Shipping Instructions:Ship at refrigerated temperature.
Test Performed at or Referral Lab Lab Sendouts  (ARUP)
Referral Lab number:80001


Interpretive

Reference Range:

0-6 y

18-90 U/L

7-14 y

24-121 U/L

15-17 y

18-101 U/L

18 y and older

9-67 U/L

 

 

Use:Significant increases in serum ACE are observed in 75% of patients with active pulmonary sarcoidosis. Rarely, ACE in serum is incresed in patients suffering from other types of lung disease such as pulmonary tuberculosis, coccidioidomycosis, lung cancer, or from other types of granulomatous disease. ACE activity is a helpful test for the differential diagnosis of sarcoidosis. Increased ACE activity has also been reported in Gaucher's disease, leprosy, silicosis, asbestosis, and in 24% of patients with diabetes mellitus. The enzyme also seems to play a key physiological role in the regulation of blood pressure. In patients with active sarcoidosis, enzyme values fall within the reference interval during spontaneous remission or after appropriate corticosteroid treatment. Therefore, the assay is useful in following the clinical course of the disease and therapy effectiveness.


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