Parietal Cell Antibody, IgG


Sunquest Code:PARIET  
Epic Code:LAB4345Epic Name:Parietal cell aby with reflex
Synonyms:Anti-parietal Cell Antibody, IgG; Gastric Parietal Cell Antibody
Methodology:Enzyme-linked immunosorbent assay
CPT Code:83516
Test Includes:Positive results are titered.
Turnaround Time:Specimens are sent to reference laboratory Mon-Sat; results are reported in 1-3 days.


Collection Instructions

Specimen:Blood
Optimal Volume:1.2 mL
Minimum\Peds Volume:0.7 mL
Container:Red or gold (gel) (Red (no gel))
Causes for Rejection:Severely lipemic or hemolyzed specimens, plasma or urine.


Processing and Shipping

Specimen Processing:Centrifuge within 2 hours of collection and aliquot 0.5 mL, 0.25 mL minimum. Store in refrigerator.
Shipping Instructions:Ship at refrigerated temperature.
Stability:Stability: After separation from cells, 48 hours at room temperature, 2 weeks refrigerated; 1 year frozen.
Test Performed at or Referral Lab Lab Sendouts  (ARUP)
Referral Lab number:50596


Interpretive

Reference Range:

Negative

0.0 – 20.0 units

Equivocal

20.1 – 24.9 units

Positive

25.0 units or greater

 

 

Use:

Circulating autoantibodies to parietal cell canaliculi, to the B12 binding site of intrinsic factor, and to the intrinsic factor B12 complex occur with high frequency (about 75%) in patients with pernicious anemia. Gastric autoimmune diseases have been classified into Type A and Type B gastritis based on the morphological changes in the fundus and antral portion of the stomach. Patients with antibodies to parietal cells (PCA) or intrinsic factor (or both) have atrophy of the fundal mucosa (Type A) and a very high rate of pernicious anemia often associated with other autoimmune endocrine disorders. A positive PCA in the presence of a megaloblastic anemia makes pernicious anemia a probable diagnosis. In Type B gastritis, PCA is lacking and there is no association with pernicious anemia or other autoimmune endocrine disorders.

 

These antibodies are also found in a number of other conditions, i.e., diabetes mellitus, Hashimoto’s disease, Sjogren’s syndrome, atrophic gastritis, gastric ulcer, thyrotoxicosis, myasthenia gravis, iron deficiency anemia, idiopathic Addison’s disease, primary myxedema and rheumatoid arthritis. In the normal population, PCA varies from 2% of normal subjects less than 20 years old up to 16% in normal subjects greater than 60 years of age.

 

Most patients with pernicious anemia have parietal cell antibodies. However, the fact that such antibodies are found with increased frequency in unaffected family members, as well as in patients with other autoimmune diseases, suggest these antibodies do not cause disease by themselves.

 



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