Hairy Cell Leukemia (HCL) NGS Panel


Sunquest Code:HAIRYCoPath Code:HAIRYNGSO
Epic Code:LAB8087Epic Name:Hairy Cell Leukemia NGS Panel
Methodology:Next generation sequencing
Test Includes:BRAF; MAP2K1
Turnaround Time:Performed Mon-Fri; results are reported within 10-14 days.


Collection Instructions

Specimen:Blood, bone marrow
Optimal Volume:10 mL blood; 3 mL bone marrow
Minimum\Peds Volume:3 mL blood; 1 mL bone marrow
Container:Yellow (ACD, Solution A) tube available from laboratory (Purple (EDTA))
Collection Instructions:Bone marrow clot acceptable for testing.
Causes for Rejection:Frozen or clotted specimen; incorrect anticoagulant; specimen more than 5 days old.
Shared blood and bone marrow samples will not be accepted unless sent to Molecular first. Contamination will occur on automated hematology analyzers.


Processing and Shipping

Specimen Processing:Do not process. Store at room temperature.
Shipping Instructions:Ship at room temperature. Do not refrigerate or freeze.
Stability:Whole blood samples are stable for 5 days at room temperature. Do not refrigerate or freeze.
Test Performed at or Referral Lab Molecular Diagnostics  (UMMC-East Bank)


Interpretive

Reference Range:See interpretive report.
Use:The vast majority of hairy cell leukemia have a BRAF V600E mutation. MAP2K1 mutations are found in hairy cell leukemia variant. It is unclear at this time if MAP2K1 mutations can be found in rare cases of classic hairy cell leukemia.


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