Thyroid Panel Focused NGS Panel

Sunquest Code:THYFOCCoPath Code:THYFOCNGSO
Epic Code:LAB8129Epic Name:Thyroid Panel Focused NGS Panel
Methodology:Next generation sequencing
Test Includes:Select regions of AKT1, BRAF, CTNNB1, EIF1AX, GNAS, HRAS, KRAS, NRAS, PIK3CA, PTEN, RET, TP53. Fusion panel analysis for RET rearrangement is a separate assay.
Turnaround Time:Performed Mon-Fri; results are reported in 10-14 days.
Special Instructions:Fixed samples: Include block number for testing.

Collection Instructions

Specimen:Fixed tissue slides
Optimal Volume:5 unstained slides (10 microns thick) and 1 H&E slide (10 microns thick) fixed tissue.
Minimum\Peds Volume:5 unstained slides (10 microns thick) and 1 H&E slide (10 microns thick) fixed tissue.
Container:Plastic leakproof container, sterile
Causes for Rejection:Tissue: Decalcified tissue, fixatives other than formalin used.

Processing and Shipping

Specimen Processing:Do not process. Store at room temperature.
Shipping Instructions:Ship at room temperature. Do not refrigerate or freeze.
Stability:Do not refrigerate or freeze.
Test Performed at or Referral Lab Molecular Diagnostics  (UMMC-East Bank)


Reference Range:See interpretive report.
Use:Clinical use: This panel detects mutations in a panel of genes associated with the development of papillary, follicular, and medullary thyroid carcinomas. Indications include diagnostic screening of indeterminate cytology thyroid nodules, guiding targeted therapy selection, and informing prognosis. Please note that this test does not detect RET gene rearrangement; please order separate Fusion Panel if clinically indicated.

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