Scleroderma (Scl-70) (ENA) Antibody, IgG
| Sunquest Code: | SCLIGG | ||
| Epic Code: | LAB6367 | Epic Name: | Scleroderma AB (Scl-70) (ENA) IgG |
| Synonyms: | SCL-70; Antitopoisomerase-1; Anti-Scleroderma Antibody | ||
| Methodology: | Multiplex flow immunoassay | ||
| Turnaround Time: | Performed Mon-Fri; results reported the same day. | ||
Collection Instructions
| Specimen: | Blood |
| Optimal Volume: | 2 mL |
| Minimum\Peds Volume: | 0.9 mL |
| Container: | Red or gold (gel) (Green (lithium heparin, gel), Green (sodium heparin, no gel), Purple (EDTA), Red (no gel)) |
| Causes for Rejection: | Gross hemolysis |
Processing and Shipping
| Specimen Processing: | Centrifuge and aliquot 1 mL, 0.35 mL minimum. Store in refrigerator up to 7 days. |
| Shipping Instructions: | Ship at refrigerated temperature. |
| Test Performed at or Referral Lab | Specialty Core (UMMC-East Bank) |
Interpretive
| Reference Range: |
Antibody index (AI) values reflect qualitative changes in antibody concentration that cannot be directly associated with clinical condition or disease state.
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| Use: | Scleroderma (Scl-70) antibody is seen in 20-60% of patients with scleroderma and is considered diagnostic and specific for scleroderma if it is the only ENA antibody present. Scl-70 is also seen in approximately 25% of progressive systemic sclerosis (PSS). |
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