Procalcitonin Grand Itasca


Sunquest Code:PCAL  
Epic Code:LAB5727Epic Name:Procalcitonin
Synonyms:PCT
Methodology:ELISA
Turnaround Time:Performed and reported 24 hours/day.


Collection Instructions

Specimen:Blood
Optimal Volume:3.0 mL
Minimum\Peds Volume:1.0 mL
Container:Green (lithium heparin, gel)
Causes for Rejection:Hemolysis, icterus and lipemia, greater than moderate. Samples greater than 4 hours at room temperature. Samples greater than 48 hours old.


Processing and Shipping

Specimen Processing:Centrifuge and aliquot 1.5 mL, 0.4 mL minimum. Samples are stable at room temperature for 4 hours and refrigerated for 48 hours. Store in refrigerator.
Shipping Instructions:Ship at refrigerated temperature.
Test Performed at or Referral Lab Chemistry  (Grand Itasca GICH)


Interpretive

Critical Range:Greater than or equal to 10 ng/mL.
Reference Range:
  Interpretation Recommendation
<0.05 ng/mL                Normal
  • Low risk of severe sepsis and/or septic shock. Does not exclude local infection in its initial stages (<6 hours).
  • It is recommended to retest procalcitonin within 6-24 hours if any concentration of <2.0 ng/mL are obtained.
0.5 to 1.99 ng/mL Moderate risk of systemic infection.
  • Values between 0.5 to 1.99 ng/mL should be interpreted considering patient's history; increased procalcitonin can occur without infection.
  • It is recommended to retest procalcitonin within 6-24 hours if any concentration of <2.0 ng/mL are obtained.
> 2.0 ng/mL High risk of severe sepsis.  
 
Use:Useful in the diagnosis of systemic bacterial infection and sepsis, and optimization of antibiotic therapy. Procalcitonin (PCT) is a calcitonin precursor produced during periods of heightened inflammation. PCT production is particularly pronounced in the presence of bacterial infection High PCT levels might indicate severe infection, and low and/or decreasing levels might assist in deciding the most appropriate time to discontinue antimicrobial therapy.


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