Streptococcus pneumoniae Antibodies, IgG (14 serotypes)


Sunquest Code:PNUCAB  
Epic Code:LAB5896Epic Name:Strep Pneumonaiae IgG Types
Synonyms:Pneumococcal Antibody; PN7; Pneumo 7
Methodology:Multiplex bead assay
CPT Code:86317
Test Includes:Includes serotypes: 1, 3, 4, 5, 6B, 7F, 8, 9N, 9V, 12F, 14, 18C, 19F, 23F.
Turnaround Time:Specimens are sent to reference laboratory Mon-Sat; results are reported in 1-2 days.
Special Instructions:Mark samples "Pre-vaccine" or "Post-vaccine" so that samples will be saved and tested simultaneously. The "post" sample should be collected 30 days after immunization.
Compliance:

This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.



Collection Instructions

Specimen:Blood
Optimal Volume:3 mL
Minimum\Peds Volume:0.7 mL
Container:Red or gold (gel) (Red (no gel))
Collection Instructions:Sample should be collected just prior to vaccination and again, at four to six weeks after vaccination.
Causes for Rejection:Plasma, hemolyzed, lipemic


Processing and Shipping

Specimen Processing:Centrifuge and aliquot 1.5 mL, 0.25 mL minimum. Store in refrigerator.
Shipping Instructions:Ship at refrigerated temperature.
Test Performed at or Referral Lab Lab Sendouts  (ARUP)
Referral Lab number:50725 (PNEUMO AB)


Interpretive

Reference Range:

Includes serotypes: 1, 3, 4, 5, 6B, 7F, 8, 9N, 9V, 12F, 14, 18C, 19F, 23F

 

All serotypes tested are present in the 23-valent pure polysaccharide pneumococcal vaccine.

 

Responder status is determined according to the ratio of postvaccination to prevaccination concentration of Pneumo-Serotype IgG antibody as follows:

·          A ratio of less than twofold is considered a nonresponder.

·          A ratio of two to fourfold is a weak responder.

·          A ratio of fourfold or greater is a good responder

 

A response to 50-70% or more of the serotypes in the vaccination is indicative of a normal response.

 



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