Mucopolysaccharides (MPS) Screen, Urine - LG884


Sunquest Code:MMMISC  
Epic Code:LAB4909Epic Name:Send Outs Misc Test
Synonyms:Glycosaminoglycans (GAGS); Lysosomal Storage Disease; MPS Test; Urine Glycosaminoglycans
Methodology:Liquid chromatography/tandem mass spectrometry (LC-MS/MS)
Turnaround Time:Specimens are sent to the reference laboratory Mon-Fri results are reported within 8 days.
Compliance:

This test was developed and its performance characteristics determined by Laboratory Medicine and Pathology, Mayo Clinic. This test has not been cleared by the U.S. Food and Drug Administration.

Associated Links:

Urine Collection Procedure



Collection Instructions

Specimen:Urine, random collection
Optimal Volume:Submit entire collection; analysis requires 2 mL, 1 mL minimum.
Minimum\Peds Volume:1 mL
Container:Plastic leakproof container, sterile
Collection Instructions:Do not administer low-molecular weight heparin prior to collection. Early morning specimen preferred.


Processing and Shipping

Specimen Processing:Mix collection well before aliquot is taken. Aliquot 2 mL,1 mL minimum. Store refrigerated.
Shipping Instructions:Ship refrigerated.
Stability:7 days at room temperature; 90 days refrigerated; 365 days frozen.
Test Performed at or Referral Lab Lab Sendouts  (Mayo)
Referral Lab number:MPSQU


Interpretive

Reference Range:
Dermatan Sulfate ≤ 1.00 mg/mmol creatinine
 
Heparan Sulfate  
≤ 4 years ≤ 0.50 mg/mmol creatinine
≥ 5 years ≤ 0.25 ,g/mmol creatinine
 
Chondroitin-6 Sulfate  
≤ 24 months ≤ 10 mg/mmol creatinine
25 months-10 years ≤ 2.50 mg/mmol creatinine
≥ 11 years ≤ 1.50 mg/mmol creatinine
 
Keratan Sulfate  
≤ 12 months ≤ 2.00 mg/mmol creatinine
13-24 months ≤ 1.50 mg/mmol creatinine
25 months-4 years ≤ 1.00 mg/mmol creatinine
5-18 years ≤ 0.50 mgmmol creatinine
≥ 19 years ≤ 0.30 mg/mmol creatinine
 
Use:Supporting the biochemical diagnosis of one of the mucopolysaccharidoses; types I, II, III, IV, VI or VII.
Monitoring patients with mucopolysaccharidosis who have had bone marrow transplants or are receiving enzyme therapy.


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