Creatinine Clearance


Sunquest Code:CRCL  
Epic Code:LAB383Epic Name:Creatinine Clearance
Order Instructions:Order UCRT. Enter collection volume, duration, height and weight.
Synonyms:Clearance, Creatinine
Methodology:Calculation
Test Includes:Urine creatinine, raw clearance and standard clearance
Turnaround Time:Performed and reported 24 hours/day.
Special Instructions:Blood creatinine must be collected within 24 hours of the urine collection. Record the patient's height and weight on request form.
Associated Links:

Urine Collection Procedure



Collection Instructions

Specimen:Urine, timed collection (12 to 24 hour; 2-12 hour collections are acceptable but not recommended)
Optimal Volume:Submit entire collection; analysis requires 0.2 mL
Container:3 L plastic jug
Collection Instructions:Refrigerate during collection. IVP dye does not interfere with sample analysis.
Patient Preparation:The patient should continue good hydration and avoid cooked meat, coffee, tea, or drugs (especially cephalotoxin and other cephalosporins) throughout the collection period.
Causes for Rejection:No serum creatinine collected; collection not timed.


Processing and Shipping

Specimen Processing:Mix collection well before aliquot is taken. Centrifuge specimens containing cells or precipitate. Aliquot 1 mL, 0.2 mL minimum. Store in refrigerator.
Shipping Instructions:Ship at refrigerated temperature.
Stability:Acceptable preservatives: HCl, or boric acid. Results should be inspected for consistency, assuming a normal collection should contain 1 g creat/24 hour. Collection on ice preferred; but not required. A clearance will be accepted and reported on patients whose serum creatinine is normal and has been collected within 72 hours of the urine collection. SI Unit Conversion Factor: clearance (mL/min) x 0.01667 = clearance (mL/s)
Test Performed at or Referral Lab Chemistry  (Fairview Range - FRMC, UMMC-East Bank, Fairview Lakes - FLMC, Fairview Ridges - FRH, Fairview Northland - FNMC, Fairview Southdale - FSH, UMMC/UMMCH-West Bank, M Health Clinic and Surgery Center)


Interpretive

Reference Range:

Standard Clearance

(calibrated to IDMS)

Female

100-160 mL/min/1.73m2

Male

110-180 mL/min/1.73m2

The calculation for standard creatinine clearance in mL/min =urine volume/minute x urine creatinine/serum creatinine x 1.73/surface area of body in m2. Body surface area is obtained using the DuBois formula (see below) which require height and weight.

 

       BSA = 0.007184 x weight (kg) 0.425 x height (m) 0.725

 

Normal ranges for children less than one year of age are not well established. Ranges seem to be lower than those of older patients.

 

Use:Evaluate renal function.


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