17-Hydroxypregnenolone Quantitative by LC-MS/MS, Serum or Plasma


Sunquest Code:PGN17  
Epic Code:LAB530Epic Name:17 OH Pregnenolone
Synonyms:17-OH-Pregnenolone
Methodology:High performance liquid chromatography/Tandem mass spectrometry
CPT Code:84143
Turnaround Time:Specimens are sent to reference laboratory Mon-Sat; results are reported in 1-4 days.
Compliance:

This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.



Collection Instructions

Specimen:Blood
Optimal Volume:2 mL
Minimum\Peds Volume:1.2 mL
Container:Red or gold (gel) (Green (sodium heparin, no gel), Purple (EDTA), Red (no gel))


Processing and Shipping

Specimen Processing:Centrifuge and aliquot within 2 hours of collection two 0.5 mL, 0.25 mL minimum aliquots. Freeze immediately.
Shipping Instructions:Ship together on dry ice.
Test Performed at or Referral Lab Lab Sendouts  (ARUP)
Referral Lab number:92333 (OHPRGNLON)


Interpretive

Reference Range:

 

Females:

Premature (26-28 w)
Premature (29-36 w)
Full Term (1-5 mo)
6 -12 mo
13-23 mo
2-4 y

5-6 y

7-9 y

10-12 y
13-15 y
16-17 y
18 y and older

 

1219-9799 ng/dL
346-8911 ng/dL
229-3104 ng/dL
less than or equal to 917 ng/dL
less than or equal to 592 ng/dL
less than or equal to 280 ng/dL
less than or equal to 350 ng/dL

less than or equal to 212 ng/dL
less than or equal to 398 ng/dL
less than or equal to 407 ng/dL
less than or equal to 423 ng/dL

less than 226 ng/dL

 

Tanner Stage I
Tanner Stage II
Tanner Stage III
Tanner Stage IV-V

less than or equal to 235 ng/dL
less than or equal to 367ng/dL
less than or equal to 430 ng/dL

less than or equal to 412 ng/dL

 

 

Males:

Premature (26-28 w)
Premature (29-36 w)
Full Term (1-5 mo)
6 -12 mo
13-23 mo
2-4 y

5-6 y

7-9 y

10-12 y
13-15 y
16-17 y
18 y and older

 

1219-9799 ng/dL
346-8911 ng/dL
229-3104 ng/dL
less than or equal to 917 ng/dL
less than or equal to 592 ng/dL
less than or equal to 249 ng/dL
less than or equal to 319 ng/dL

less than or equal to 187 ng/dL
less than or equal to 392 ng/dL
35 465 ng/dL
32 478 ng/dL

less than 442 ng/dL

 

Tanner Stage I
Tanner Stage II
Tanner Stage III
Tanner Stage IV-V

less than or equal to 208 ng/dL
less than or equal to 355 ng/dL
less than or equal to 450 ng/dL
35-478 ng/dL

 

 

 

Use:Diagnosis of congenital adrenal hyperplasia (CAH) due to deficiency of 21-hydroxylase.


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