Esterase, Alpha Naphthyl Butyrate (Esterase, Nonspecific) Stain

Order Instructions:Must be ordered by a pathologist.
Synonyms:Bone Marrow Cytochemistry and Histochemistry; Cytochemistry Leukocyte; Leukocyte Cytochemistry and Histochemistry
CPT Codes: 88319 x1, 8831926-26 x1, 88319-26 x1
Test Includes:Esterase, Nonspecific Stain. If requested, interpretation by pathologist is performed at an additional charge.
Turnaround Time:Performed Mon-Fri; 0730-1600. Preliminary results are available in 24 hours, final results are reported within 48 hours.
Special Instructions:If an interpretation is not requested, slides will be returned to the sender.

Collection Instructions

Specimen:Blood or bone marrow smears or imprints
Container:Microscope slides
Collection Instructions:Provide 3-4 unstained blood smears (prepared from fresh blood or EDTA sample), bone marrow smears or imprints. This test cannot be performed on section material.

Processing and Shipping

Specimen Processing:Store at room temperature.
Shipping Instructions:Ship slides in protective slide holder at room temperature.
Test Performed at or Referral Lab UM Special Hematopathology (P)  (UMMC East Bank)


Reference Range:Interpretive report by hematopathologist, upon request.
Use:The nonspecific esterase stain is of particular value in the recognition of acute monocytic or myelomonocytic leukemias. The stain is also positive in malignant histiocytosis and histiocytic lymphoma. The nonspecific esterase stain has also been utilized for the recognition of mature T lymphocytes and the cells of hairy cell leukemia. A variable percentage of leukemic cells in a high percent of cases of hairy cell leukemia will show focal areas of nonspecific esterase positivity.

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