Acetylcholine Receptor Modulating Antibody


Abbrev Code:ACRMOD   
Order Code:LAB837Order Name:Acetylcholine Receptor Modulating Antibody
Synonyms:AChR Modulating Antibody; Anticholinesterase Antibody
Methodology:Flow cytometry
CPT Codes: 83519 x1
Turnaround Time:Specimens are sent to reference laboratory Mon-Sat; results are reported in 2-7 days.
Compliance:

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the U.S. Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.



Collection Instructions

Specimen:Blood
Optimal Volume:1 mL
Minimum\Peds Volume:0.8 mL
Container:Red or gold (gel)
Alternate Containers: Red (no gel)
Causes for Rejection:Severely lipemic; contaminated or hemolyzed specimens.


Processing and Shipping

Specimen Processing:Separate serum from cells ASAP. Centrifuge and aliquot 0.5 mL, 0.3 mL minimum. Store in refrigerator.
Shipping Instructions:Ship at refrigerated temperature.
Stability:Stability: After separation from cells - 2 hours at room temperature; 2 weeks refrigerated; 1 year frozen.
Test Performed at or Referral Lab Lab Sendouts  (ARUP)
Referral Lab number:99521


Interpretive

Reference Range:
Negative 0-45% modulation
Positive 46% or greater modulation
   
Use:Approximately 85-90% of patients with myasthenia gravis (MG) express antibodies to the acetylcholine receptor (AChR), which can be divided into binding, blocking and modulating antibody. Binding antibody can activate complement and lead to loss of AChR. Blocking antibody may impair AChR binding to the receptor leading to poor muscle contraction. Modulating antibody causes receptor endocytosis resulting in loss of AChR expression, which correlates most closely with clinical severity of disease. Approximately 10-15% of individuals with confirmed myasthenia gravis have no measurable binding, blocking or modulating antibody.


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