Bone Marrow Aspirate and Trephine Biopsy, Collection and Morphology

Abbrev Code:CBM   
Order Code:LAB6  
Synonyms:Trephine Biopsy with Bone Marrow Collection; Biopsy, Bone Marrow Aspirate/Trephine
Methodology:Aspiration, biopsy collection and microscopic analysis by pathologist
CPT Codes: 38220 x1, 38220 x1, 85097 x1, 85097-26 x1, 88305 x1, 8830526-26 x1, 85060 x1, 38221 x1, 38221 x1, 88305-26 x1, 85097 x1
Test Includes:Collection of bone marrow aspirate and/or trephine biopsy. Examination of bone marrow aspirate and/or trephine biopsy, and peripheral blood smears.
Turnaround Time: Preliminary results are available in 24-36 hours. Final results are reported within 72 hours.
Special Instructions:When scheduling, indicate requested specimen (aspirate and/or trephine biopsy), cultures or special testing orders (FISH and Chromosome analysis. Process and hold DNA. Leukemia lymphoma evaluation, etc.). Provide a clinical history including a list of current medications. For emergent or after hour procedures contact the on-call hematopathology fellow or pathologist on call

Collection Instructions

Specimen:Bone marrow and peripheral blood
Optimal Volume:2-5 mL of bone marrow (in EDTA) and 1-2 cm of bone marrow core (trephine) in fixative.
Minimum\Peds Volume:0.3 mL aspirate (in EDTA)
Container:Microscope slides
Patient Preparation:A physician will explain the procedure, obtains consent, and performs an aseptic collection procedure.
After Care:Instruct patient to lie on site of biopsy for 20-30 minutes. Keep the biopsy site dry for 24 hours and follow any additional physician's directions.
Contraindications:Hemophiliacs and patients on anticoagulants should be properly prepared. Patients sensitive to local anesthetics should be identified.

Processing and Shipping

Test Performed at or Referral Lab UM Special Hematopathology (P)  (Lakes, Northland, Ridges, Southdale, UMMC East Bank)


Reference Range:Interpretive report by hematopathologist or pathologist.
Use:Evaluation of patients with suspected disorders of the hematopoietic system including all forms of leukemia, anemia, lymphoma, myeloma and metastatic malignancies. Nonmalignant disorders in which bone marrow biopsies are appropriate are suspected infectious processes (culture and examine for granulomas) and inherited metabolic disorders.

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