Amino Acids, CSF


Abbrev Code:CAA, CAA1, CAA25   
Order Code:LAB3012, LAB3013, LAB3014Order Name:Amino Acid Quantitative CSF
Order Instructions:If a single amino acid is requested, order CAA1 (LAB3012) and specify amino acid required; otherwise, order CAA (LAB3013). If 2-5 amino acids are requested, order CAA25 (LAB3014) and specify the amino acids required.
Synonyms:AA; Asparagine; Aspartic Acid; Carnosine; Citrulline; Half-cystine; Cystathionine; Glutamic Acid; Glutamine; Glycine; Histidine; Homocystine; Hydroxylysine; Isoleucine; Leucine; Lysine; Methionine; 1-methylhistidine; 3-methylhistidine; Ornithine; Phenylalanine; Proline; Sarcosine; Serine; Taurine; Threonine; Tyrosine; Valine; Alanine; B-alanine; A-aminoadipic Acid; B-aminoisobutyric Acid; Anserine; Arginine; Argininosuccinic Acid; Hydroxyproline
Methodology:High performance ion exchange liquid chromatography
CPT Codes: 82131 x1, 82136 x1, 82139 x1
Test Includes:Alanine, B-alanine, A-aminoadipic acid, B-aminoisobutyric acid, anserine, arginine, argininosuccinic acid, asparagine, aspartic acid, carnosine, citrulline, cystine, cystathionine, glutamic acid, glutamine, glycine, histidine, homocystine, hydroxylysine, hydroxyproline, isoleucine, leucine, lysine, methionine, 1-methylhistidine, 3-methylhistidine, ornithine, phenylalanine, proline, sarcosine, serine, taurine, threonine, tyrosine, valine.
Turnaround Time:Performed Mon-Fri; results are reported the next day.
Special Instructions:Provide clinical history and specify amino acid(s) desired on request form.


Collection Instructions

Specimen:CSF
Optimal Volume:0.5 mL
Minimum\Peds Volume:0.3 mL
Container:Sterile tube
Alternate Containers: Plastic leakproof container, sterile
Causes for Rejection:Sample not separated from cells and frozen within 2 hours of collection.


Processing and Shipping

Specimen Processing:Within 2 hours, centrifuge and aliquot 0.5 mL, 0.25 mL minimum. Room temperature or refrigerated samples must arrive at Biochemical Genetics within 2 hours of collection (preferred). Alternately, store specimen in the freezer and ship on ice.
Shipping Instructions:Ship on dry ice.
Stability:2 hours at room temperature or refrigerated; 14 days frozen.
Test Performed at or Referral Lab UM Special Drug/Biochemical Genetics (Y)  (UMMC East Bank)


Interpretive

Reference Range:

An interpretation of the report can be requested.

 

 

umol/dL

Alanine

1.3-3.7

Arginine

<3.0

Aspartic acid

<1.0

Glutamic acid

<11.8

Glutamine

0-2 wk

 

46.5-86.2

2 wk-6 mo

40.4-77.3

6-12 mo

34.2-63.0

12-30 mo

24.6-49.3

>30 mo

16.1-53.3

Glycine

<2.1

Histidine

<3.2

Isoleucine

<1.6

Leucine

<1.9

Lysine

1.3-4.2

Methionine

<1.0

Ornithine

<1.0

Phenylalanine

<1.1

Proline

<1.0

Serine

1.3-7.0

Taurine

<1.5

Threonine

1.0-5.1

Tyrosine

<1.2

Valine

<2.7

 

 

Use:To monitor glutamine for hyperammonemia, glycine to diagnose nonketotic hyperglycinemia, or other amino acids in cerebrospinal fluid.


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