Renin Activity to ARUP

Abbrev Code:RENIN   
Order Code:LAB532Order Name:Renin Activity
CPT Codes: 84244 x1
Turnaround Time:Specimens are sent to the reference laboratory Mon-Sat; results are reported within 1-3 days.

Collection Instructions

Optimal Volume:4 mL
Minimum\Peds Volume:2.6 mL
Container:6 mL Purple EDTA tube
Alternate Containers: Pink (EDTA)
Collection Instructions:Collect into a 6 mL EDTA tube or two 3 mL EDTA tubes.
Whole blood specimens should not be chilled or placed on ice because of irreversible cryoactivation of prorenin can occur leading to falsely elevated results.
Patient Preparation:Collect mid-morning after patient has been sitting, standing or walking for at least 2 hours and seated for 5-15 minutes. Normal sodium diet (100-200 mEq/day) for at least three days. Receiving no medications known to affect renin-aldosterone system.
Contraindications:Refrigerated specimen; serum, heparin, citrate or oxalate plasma, hemolyzed specimens.

Processing and Shipping

Specimen Processing:Centrifuge ASAP after collection and aliquot 2 mL, 1.2 mL minimum plasma. Freeze immediately.
Shipping Instructions:Ship on dry ice.
Stability:6 hours at room temperature; 1 month frozen.
Test Performed at or Referral Lab Lab Sendouts  (ARUP)
Referral Lab number:70105


Reference Range:



Adult, Normal Sodium Diet





Children, Normal Sodium Diet, Supine

1-12 mo


13 mo-3 y


4-5 y


6-10 y


11-15 y


Children, Normal Sodium Diet, Upright
0-3 y N/A
4-5 y ≤15
6-10 y ≤17
11-15 y ≤16

Newborn (1-7 days)


Cord Blood



Note: Plasma renin activity measures enzyme ability to convert angiotensinogen to angiotensin I and is limited by the availability of angiotensinogen. Plasma rennin activity is not an accurate indicator of enzyme activity when angiotensinogen is decreased. Renin, Direct measures the actual concentration of rennin in the plasma, and therefore is not dependent on angiotensinogen concentration.



The measurement of plasma renin activity (PRA) may be useful in determining whether hypertension is due to primary hyperaldosteronism or renal vascular disease. PRA is suppressed in primary hyperaldosteronism, whereas PRA and aldosterone are both elevated in secondary hyperaldosteronism (renovascular hypertension). The plasma renin and aldosterone ratio is used to screen patients with hypokalemia and possible hyperaldosteronism.


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