Arginine Vasopressin Hormone


Abbrev Code:VASO   
Order Code:LAB1108Order Name:Arginine Vasopressin Hormone
Synonyms:Vasopressin, Plasma; ADH; Anti-Diuretic Hormone
Methodology:Radioimmunoassay
CPT Codes: 84588 x1
Turnaround Time:Specimens are sent to reference laboratory Mon-Sat; results are reported in 3-11 days.
Compliance:

For tests developed and validated by ARUP (previously referred to as Compliance Statement B, C or D). This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the U.S. Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.


Collection Instructions

Specimen:Blood
Optimal Volume:12 mL
Minimum\Peds Volume:5.2 mL
Container:Purple (EDTA)


Processing and Shipping

Specimen Processing:Centrifuge and aliquot 6 mL, 2.5 mL minimum. Separate samples must be submitted when multiple tests are ordered. Separate plasma from cells ASAP. Freeze within 2 hours.
Shipping Instructions:Ship on dry ice.
Stability:2 hours at room temperature or refrigerated; 1 month frozen.
Test Performed at or Referral Lab Lab Sendouts  (ARUP)
Referral Lab number:70027


Interpretive

Reference Range:0.0-6.9 pg/mL
Use:Arginine vasopressin hormone (AVP) also known as anti-diuretic hormone (ADH) is important in the regulation of water permeability of renal collecting tubules and the ascending loop of Henle. It is also a vasoconstrictor and probably plays a role in arterial pressure maintenance during blood loss.

Inadequate AVP function results in polyuric states:
  • Hypothalamic diabetes insipidus (HDI), characterized by inadequate pituitary AVP production, and high serum osmolality and low or normal AVP levels
  • Nephrogenic diabetes insipidus (NDI), characterized by lack of renal response to AVP, with high serum osmolality and high AVP levels
  • Psychogenic polydipsia (PP), characterized by excessive water ingestion with AVP levels normal for their plasma osmolality.


Excess AVP function results in the syndrome of inappropriate ADH secretion (STADH) with hypo-osmolality and hyponatremia AVP levels are inappropriately high for the serum or urine osmolality. If renin is measured at the same time it would be low in STADH.

AVP must be interpreted along with both plasma and urine osmolality. A first morning urine sample (osmolality <300 mosm/kg and simultaneous plasma osmolality >310 mosm/kg) is diagnostic of a severe or complete form of diabetes insipidus (neurogenic or nephrogenic) and obviates water deprivation.  


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