Glucose-6-Phosphate Dehydrogenase
Abbrev Code: | G6PDH | ||
Order Code: | LAB571 | Order Name: | Glucose 6 Phosphate Dehydrogenase |
Synonyms: | G-6-PDH; G6PD | ||
Methodology: | Enzymatic | ||
CPT Codes: | 82955 x1 | ||
Turnaround Time: | Specimens are sent to reference laboratory Mon-Sat; results are reported in 1-3 days. |
Collection Instructions
Specimen: | Blood |
Optimal Volume: | 3 mL |
Minimum\Peds Volume: | 1.5 mL |
Container: | Yellow (ACD, Solution A) tube available from laboratory Alternate Containers: Green (lithium heparin, no gel), Green (sodium heparin, no gel), Purple (EDTA) |
Causes for Rejection: | Clotted, hemolyzed or frozen specimens. |
Processing and Shipping
Specimen Processing: | Whole blood. Do not process. Store in refrigerator. Do not freeze. |
Shipping Instructions: | Ship at refrigerated temperature. |
Test Performed at or Referral Lab | Lab Sendouts (ARUP) |
Referral Lab number: | 80135 (G6PD) |
Interpretive
Reference Range: | Effective Nov 17, 2014: 9.9-16.6 U/g Hg Note: Patients who have recently received transfusions have normal donor cells that may mask G-6-PD deficient erythrocytes. |
Use: |
Glucose-6-phosphate dehydrogenase (G-6-PD) catalyzes the first step in the pentose phosphate pathway, oxidizing glucose-6-phosphate to 6-phosphogluconate and reducing NADP to NADPH. G-6-PD deficiency in erythrocytes is a major cause of congenital non-spherocytic hemolytic anemia.
This deficiency affects approximately 200 million people worldwide, especially those individuals originating from Southeast Asia, Africa, the Mediterranean and India. In this disorder of RBC metabolism, a decreased enzyme level is found in older erythrocytes, resulting in RBC lysis in response to certain drugs (primaquine, chloramphenicol, acetanilide, phenacetin, vitamin K, sulfonamides and nitrofurans). Variants of G-6-PD-deficiency differ in the degree of residual enzyme activity (severe to mild). Severe deficiency decreases the RBC life span to such an extent that a chronic hemolytic anemia with jaundice is found even in the absence of a drug challenge, Females with G-6-PD deficiency may have difficulty in carrying pregnancy to term, possibly because of the effect of changing hormones on the sensitive RBCs.
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