Serotonin, Whole Blood

Abbrev Code:SEROWB   
Order Code:LAB6045Order Name:Serotonin, Whole Blood
Methodology:High performance liquid chromatography
CPT Codes: 84260 x1
Turnaround Time:Specimens are sent to reference laboratory Mon-Sat; results are reported in 1-5 days.
Special Instructions:Serum serotonin is recommended for pediatric patients and patients that are difficult to draw.

For tests developed and validated by ARUP (previously referred to as Compliance Statement B, C or D). This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the U.S. Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.

Collection Instructions

Optimal Volume:3 mL
Minimum\Peds Volume:1 mL
Container:Purple (EDTA)
Alternate Containers: Pink (EDTA)
Collection Instructions:Place specimen on ice and send to laboratory immediately after collection.
Patient Preparation:Abstain from medications 72 hours prior to collection.
Causes for Rejection:Non-frozen samples, samples frozen in glass tubes

Processing and Shipping

Specimen Processing:Process immediately after collection. Place 3 mL; 1 mL minimum EDTA whole blood into a whole blood serotonin collection tube (containing ascorbic acid), available from the laboratory or Client Services. Mix well and freeze within 2 hours.
Shipping Instructions:Ship on dry ice.
Test Performed at or Referral Lab Lab Sendouts  (ARUP)
Referral Lab number:80395 (SEROT-WB)


Reference Range:50-200 ng/mL In general, EDTA whole blood (as compared to serum) transported with ascorbic acid preservative will give values most representative of blood concentrations. 95% of blood serotonin is typically found in platelets.

Medications which may affect serotonin concentrations include: lithium, MAO inhibitors, methyldopa, morphine and reserpine. In general, serotonin-containing foods do not interfere significantly.


Slight increases may be seen in dumping syndromes, acute intestinal obstruction, cystic fibrosis, acute myocardial infarction (MI), and nontropical sprue.


Metastasizing abdominal carcinoid tumors will often produce concentrations greater than 400 ng/mL.


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