Pyruvate Kinase, RBC
| Abbrev Code: | PKIN | ||
| Order Code: | LAB1087 | Order Name: | Pyruvate Kinase |
| Methodology: | Enzymatic | ||
| CPT Codes: | 84220 x1 | ||
| Turnaround Time: | Specimens are sent to reference laboratory Mon-Sat; results are reported in 1-2 days. | ||
| Special Instructions: | Patients who have been recently transfused have normal donor cells that may mask PK deficient erythrocytes. | ||
Collection Instructions
| Specimen: | Blood |
| Optimal Volume: | 3 mL |
| Minimum\Peds Volume: | 1 mL |
| Container: | Purple (EDTA) Alternate Containers: Green (lithium heparin, no gel), Green (sodium heparin, no gel), Pink (EDTA), Yellow (ACD, Solution A) tube available from laboratory |
Processing and Shipping
| Specimen Processing: | Do not centrifuge, whole blood. Aliquot 3 mL, 1 mL minimum. Store in refrigerator. |
| Shipping Instructions: | Ship at refrigerated temperature. |
| Test Performed at or Referral Lab | Lab Sendouts (ARUP) |
| Referral Lab number: | 80290 |
Interpretive
| Reference Range: | 4.6-11.2 U/g hemoglobin |
| Use: | A deficiency of the glycolytic enzyme, pyruvate kinase (PK) is one of the most common causes of congenital non-spherocytic hemolytic anemia. In this genetic deficiency, the enzyme PK is deficient in RBCs. The clinical expression, which is variable in its severity, requires that both chromosomes carry the defect. Carriers can be recognized by the fact that their erythrocytes contain about half the normal PK activity. The diagnostic significance of elevated serum PK levels has not been determined. Many disease states associated with anemias show elevated RBC PK levels. |
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