Factor 2 Activity
Abbrev Code: | F2 | ||
Order Code: | LAB303 | Order Name: | Factor 2 Assay |
Synonyms: | Prothrombin Assay; Factor II Activity | ||
Methodology: | Thromboplastin clotting time correction of Factor 2 deficient plasma. Patient dilutions are compared to a known set of standard dilutions and a percentage is determined. | ||
CPT Codes: | 85210 x1, 85210 x1 | ||
Turnaround Time: | Within 8 hours if received into the testing laboratory by 12 p.m. Testing performed 6 days per week. With pre-notification, STATs are done within 1 hour after receipt in the testing laboratory. | ||
Special Instructions: | This test is different from the Prothrombin 20210 Mutation PCR test. | ||
Associated Links: | Specimen Collection and Processing for Coagulation Specimens |
Collection Instructions
Specimen: | Blood |
Optimal Volume: | 2.7 mL (in 3 mL tube) - filled to fill line on the tube. |
Minimum\Peds Volume: | 1.8 mL (in 2 mL tube) - filled to fill line on the tube. |
Container: | Blue Na Citrate, 3.2% - fill to fill line on tube |
Collection Instructions: | See link to Specimen Collection and Processing for Coagulation Specimens. |
Causes for Rejection: | Underfilled tubes, overfilled tubes, clotted specimens, not received or processed and frozen within 4 hours of collection or, specimen thawed during transit. |
Processing and Shipping
Specimen Processing: |
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Shipping Instructions: |
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Test Performed at or Referral Lab | UM Special Coag (K) (UMMC East Bank) |
Interpretive
Critical Range: | Less than 10% | ||||||||||||||
Reference Range: |
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Therapeutic Range: | With Coumadin therapy: 15-25% | ||||||||||||||
Use: | Factor 2 is a common pathway factor. A deficiency can result in a moderately severe bleeding disorder. Also used to monitor Coumadin therapy in patients with lupus inhibitors. Factor 2 is dependent on Vitamin K for its carboxylation. It is decreased in Vitamin K deficiency/Coumadin therapy. Prothrombin is the clinically critical factor that needs to be reduced to have effective anticoagulation with Coumadin. Therapeutic level for Coumadin therapy is 15-25%. |
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