Factor 8 Activity


Abbrev Code:F8   
Order Code:LAB306Order Name:Factor 8 Assay
Synonyms:AHG (Antihemophilic Globulin); Anti-Hemophilic Factor; Factor VIII Activity
Methodology:APTT clotting time correction of factor 8 deficient plasma. Patient dilutions are compared to a known set of standard dilutions and a percentage is determined.
CPT Codes: 85240 x1
Turnaround Time:Turnaround time is 4-8 hours if received during lab hours (see Associated Link). With pre-notification, stats are done within 1 hr after receipt in the laboratory.
Special Instructions:See link to Specimen Collection and Processing for Coagulation Specimens.
Associated Links:

Specimen Collection and Processing for Coagulation Specimens


Collection Instructions

Specimen:Blood
Optimal Volume:2.7 mL (in 3 mL tube) - filled to fill line on the tube.
Minimum\Peds Volume:2.7 mL (in 3 mL tube) - filled to fill line on the tube.
Container:Blue Na Citrate, 3.2% - fill to fill line on tube
Collection Instructions:See link to Specimen Collection and Processing for Coagulation Specimens.
Causes for Rejection:Underfilled tube or clotted specimens. Patients on Hemlibra® (emicizumab).


Processing and Shipping

Specimen Processing:See link to Specimen Collection and Processing for Coagulation Specimens.
Shipping Instructions:See link to Specimen Collection and Processing for Coagulation Specimens.
Test Performed at or Referral Lab Special Coagulation  (UMMC-East Bank)


Interpretive

Critical Range:Less than 10%
Reference Range:

Less than 1 d

61-194%

1-4 d

61-139%

5-29 d

55-121%

30-89 d

58-124%

90-179 d

56-102%

180-364 d

55-91%

1 y and older

55-200%

 

 

Use:

Factor 8 is an intrinsic coagulation pathway factor. Its congenital deficiency is commonly called Hemophilia A. The test is used to diagnosis Hemophilia A, von Willebrand’s Disease and acquired inhibitors to Factor 8. These conditions can lead to life-threatening bleeding. Also used to monitor various forms of Factor 8 concentrate infusion therapy.

 



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