Factor 10 Activity
| Sunquest Code: | F10 | ||
| Epic Code: | LAB3458 | Epic Name: | Factor 10 Assay |
| Synonyms: | Stuart Prower Factor; Factor X Activity | ||
| Methodology: | Thromboplastin clotting time correction of Factor 10 deficient plasma. Patient dilutions are compared to a known set of standard dilutions and a percentage is determined. | ||
| Turnaround Time: | Turnaround time is 4-8 hours if received during lab hours (See Associated Link). With pre-notification, stats are done within 1 hr after receipt in the laboratory. | ||
| Special Instructions: | THIS TEST IS NOT TO BE USED TO MONITOR HEPARIN THERAPY. THE HEPARIN (ANTI-XA) ASSAY IS USED TO MONITOR HEPARIN. This test is not recommended for monitoring Coumadin therapy in patients with Lupus-like inhibitors. Chromogenic Factor 10 or Factor 2 is used to monitor Coumadin therapy in patients with Lupus inhibitors. | ||
| Associated Links: | Specimen Collection and Processing for Coagulation Specimens |
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Collection Instructions
| Specimen: | Blood |
| Optimal Volume: | 2.7 mL (in 3 mL tube) - filled to fill line on the tube. |
| Minimum\Peds Volume: | 1.8 mL (in 2 mL tube) - filled to fill line on the tube. |
| Container: | Blue Na Citrate, 3.2% - fill to fill line on tube |
| Collection Instructions: | See link to Specimen Collection and Processing for Coagulation Specimens. |
| Causes for Rejection: | Underfilled tube or clotted specimens. |
Processing and Shipping
| Specimen Processing: | See link to Specimen Collection and Processing for Coagulation Specimens. |
| Shipping Instructions: | See link to Specimen Collection and Processing for Coagulation Specimens. |
| Test Performed at or Referral Lab | Special Coagulation (UMMC-East Bank) |
Interpretive
| Critical Range: | Less than 10% | ||||||||||||||
| Reference Range: |
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| Use: | Factor 10 is a common pathway factor. A deficiency can result in a moderately severe bleeding disorder. Factor 10 is dependent on Vitamin K for its carboxylation. It should not, however, be used to monitor Coumadin therapy in patients with Lupus-like inhibitors. Since Prothrombin is the clinically critical factor that needs to be reduced to have effective anticoagulation with Coumadin, Factor 2 is recommended. For laboratories that cannot assay an accurate Factor 2 clotting test in the presence of a lupus inhibitor, Chromogenic Factor 10 is recommended. |
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