Factor 10 Activity


Abbrev Code:F10   
Order Code:LAB3458Order Name:Factor 10 Assay
Synonyms:Stuart Prower Factor; Factor X Activity
Methodology:Thromboplastin clotting time correction of Factor 10 deficient plasma. Patient dilutions are compared to a known set of standard dilutions and a percentage is determined.
CPT Codes: 85260 x1, 85260 x1
Turnaround Time:Within 8 hours if received into the testing laboratory by 12 p.m. Testing performed 6 days per week. With pre-notification, STATs are done within 1 hour after receipt in the testing laboratory.
Special Instructions:THIS TEST IS NOT TO BE USED TO MONITOR HEPARIN THERAPY. THE HEPARIN (ANTI-XA) ASSAY IS USED TO MONITOR HEPARIN. This test is not recommended for monitoring Coumadin therapy in patients with Lupus-like inhibitors. Chromogenic Factor 10 or Factor 2 is used to monitor Coumadin therapy in patients with Lupus inhibitors.
Associated Links:

Specimen Collection and Processing for Coagulation Specimens



Collection Instructions

Specimen:Blood
Optimal Volume:2.7 mL (in 3 mL tube) - filled to fill line on the tube.
Minimum\Peds Volume:1.8 mL (in 2 mL tube) - filled to fill line on the tube.
Container:Blue Na Citrate, 3.2% - fill to fill line on tube
Collection Instructions:See link to Specimen Collection and Processing for Coagulation Specimens.
Causes for Rejection:Underfilled tubes, overfilled tubes, clotted specimens, not received or processed and frozen within 4 hours of collection or, specimen thawed during transit.


Processing and Shipping

Specimen Processing:
  • Process for Platelet Poor Plasma within 4 hours of collection.
  • Aliquot plasma, place clear tape around label, and freeze at -20C or on dry ice within 4 hours of collection.
  • If multiple tests are collected on 1 blue top, split each blue top into 2 aliquots. Minimum 0.5 mL per tube.
  • A maximum of 6 aliquots are needed per collection.
     
See link to Specimen Collection and Processing for Coagulation Specimens.
Shipping Instructions:
  • Ensure specimen is frozen before shipping.
  • Ship on dry ice, sample must remain frozen during shipping.
     
See link to Specimen Collection and Processing for Coagulation Specimens.
Test Performed at or Referral Lab UM Special Coag (K)  (UMMC East Bank)


Interpretive

Critical Range:Less than 10%
Reference Range:

Less than 1 d

22-72%

1-4 d

26-54%

5-29 d

34-64%

30-89 d

45-73%

90-179 d

53-89%

180-364 d

58-98%

1 y and older

60-140%

 

 

Use:Factor 10 is a common pathway factor. A deficiency can result in a moderately severe bleeding disorder. Factor 10 is dependent on Vitamin K for its carboxylation. It should not, however, be used to monitor Coumadin therapy in patients with Lupus-like inhibitors. Since Prothrombin is the clinically critical factor that needs to be reduced to have effective anticoagulation with Coumadin, Factor 2 is recommended. For laboratories that cannot assay an accurate Factor 2 clotting test in the presence of a lupus inhibitor, Chromogenic Factor 10 is recommended.


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