Plasminogen Activity


Abbrev Code:PLASCH   
Order Code:LAB847Order Name:Plasminogen Activity
Synonyms:Plasminogen Functional Assay; Plasminogen Chromogenic
Methodology:Chromogenic (synthetic substrate) activity assay
CPT Codes: 85420 x1, 85420 x1
Turnaround Time:Testing performed as needed; results will be reported within 2 days of receiving in the testing laboratory. With pre-notification, STATs are done within 1 hour after receipt in the testing laboratory.
Associated Links:

Specimen Collection and Processing for Coagulation Specimens


Collection Instructions

Specimen:Blood
Optimal Volume:2.7 mL (in 3 mL tube) - filled to fill line on the tube.
Minimum\Peds Volume:1.8 mL (in 2 mL tube) - filled to fill line on the tube.
Container:Blue Na Citrate, 3.2% - fill to fill line on tube
Collection Instructions:See link to Specimen Collection and Processing for Coagulation Specimens.
Causes for Rejection:Underfilled tubes, overfilled tubes, clotted specimens, not received or processed and frozen within 4 hours of collection or, specimen thawed during transit.


Processing and Shipping

Specimen Processing:
  • Process for Platelet Poor Plasma within 4 hours of collection.
  • Aliquot plasma, place clear tape around label, and freeze at -20C or on dry ice within 4 hours of collection.
  • If multiple tests are collected on 1 blue top, split each blue top into 2 aliquots. Minimum 0.5 mL per tube.
  • A maximum of 6 aliquots are needed per collection.
     
See link to Specimen Collection and Processing for Coagulation Specimens.
Shipping Instructions:
  • Ensure specimen is frozen before shipping.
  • Ship on dry ice, sample must remain frozen during shipping.
     
See link to Specimen Collection and Processing for Coagulation Specimens.
Test Performed at or Referral Lab UM Special Coag (K)  (UMMC East Bank)


Interpretive

Reference Range:
>1 year old 80-133%
Age specific reference ranges have not been established for patients 0-1 years old.
Use:Plasmin (the active form of Plasminogen) is part of the fibrinolytic system. It lyses fibrinogen and fibrin. Deficiencies are associated with arterial and venous thromboses. The Chromogenic (activity) assay detects the function of the molecule.


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