Digoxin Level

Abbrev Code:DIGX   
Order Code:LAB23Order Name:Digoxin Level
Synonyms:Lanoxin Level; DIGX
Methodology:Grand Itasca: Homogenous enzyme immunoassay
St Johns/St Joseph/ Woodwinds: Chemiluminescent microparticle immunoassay (CMIA)
All other sites: Turbidmetric rate
CPT Codes: 80162 x1
Turnaround Time:Performed and reported 24 hours/day.
Special Instructions:Elevated results may occur if blood is collected less then 6 hours after last dose.

Collection Instructions

Optimal Volume:2.5 mL
Minimum\Peds Volume:0.6 mL
Container:Red (no gel), St Johns/St Joseph/Woodwinds-Green (lithium heparin, no gel)
Alternate Containers: St Johns/St Joseph/Woodwinds - Red (no gel)
Collection Instructions:Collect a minimum of 6 hours after last dose.
Causes for Rejection:Gross hemolysis; collected less than 6 hours post dose.
Contraindications:Do not order level if patient is on digitoxin or any other cardiac glycoside.

Processing and Shipping

Specimen Processing:Centrifuge and aliquot within 2 hours of collection 1.25 mL, 0.2 mL minimum. Store in refrigerator.
Shipping Instructions:Ship at refrigerated temperature.
Stability:Stability: Room temperature - 8 hours; refrigerated - 7 days; frozen - 6 months.
Test Performed at or Referral Lab Chemistry  (Range, UMMC-East Bank, Lakes, Ridges, Northland, Southdale, UMMC/UMMCH-West Bank, Grand Itasca, St. Joseph's, St. John's, Woodwinds)


Critical Range:Greater than 2.5 ug/L
Therapeutic Range:All ages: 0.5-2.0 ug/L.
The reference range for infants (0-2 mo) is thought to be closer to 3.0-4.0 ug/L; infants tolerate more digoxin because they have more binding sites and an increased metabolic rate.
Use:Monitor therapeutic dosing and evaluate toxicity. Half-life is 36-44 h (adult); 12-24 h (child); 18-33 h (infant); and 35-88 h (neonate).

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