Clomipramine and Desmethylclomipramine

Abbrev Code:CLOMI   
Order Code:LAB1200Order Name:Clomipramine and Desmethylclomipramine
Methodology:Quantitative liquid chromatography/Tandem mass spectrometry
CPT Codes: 80335 x1, 80335 x1
Test Includes:Clomipramine and desmethylclomipramine (norclomipramine).
Turnaround Time:Specimens are sent to the reference laboratory Sun-Sat; testing is performed Mon, Wed, Fri; results are reported within 1-5 days.

ARUP Laboratory Developed Test (LDT): For tests developed and validated by ARUP (previously referred to as Compliance Statement B, C or D). This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.

Collection Instructions

Optimal Volume:6 mL
Minimum\Peds Volume:1.4 mL
Container:Red (no gel)
Alternate Containers: Purple (EDTA)
Collection Instructions:Timing of specimen collection: Pre-dose (trough) draw - At steady state concentration.
Causes for Rejection:If collected as whole blood, or in gel separator, light blue (citrate) or yellow (SPS or ACD solution) tubes.

Processing and Shipping

Specimen Processing:Centrifuge and separate serum or plasma from cells within 2 hours of collection: Aliquot 1 mL, 0.5 mL minimum serum or plasma. Store in refrigerator.
Shipping Instructions:Ship at refrigerated temperature.
Stability:After separation from cells: 5 days at room temperature; 2 weeks refrigerated; 6 months frozen.
Test Performed at or Referral Lab Lab Sendouts  (ARUP)
Referral Lab number:99336


Critical Range:Toxic: >900 ng/mL
Therapeutic Range:Total (Clomipramine and Desmethylclomipramine): 220-500 ng/mL
The therapeutic range listed relates to the antidepressant characteristics of the drug. A therapeutic range for treating obsessive compulsive disorder is not well established. Toxic concentrations may cause anticholinergic effects, CNS depression, cardiac abnormalities, seizures and hypotension.
Use:Optimize drug therapy and monitor patient adherence.

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