Imipramine and Desipramine
| Sunquest Code: | IMIPRM | ||
| Epic Code: | LAB684 | Epic Name: | Imipramine Level |
| Synonyms: | Tofranil | ||
| Methodology: | Liquid chromatography/Tandem mass spectrometry | ||
| Test Includes: | Imipramine, Desipramine (metabolite) | ||
| Turnaround Time: | Specimens are sent to reference laboratory Mon-Fri; results are reported within 3 days. | ||
| Compliance: | This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration. |
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Collection Instructions
| Specimen: | Blood |
| Optimal Volume: | 4 mL |
| Minimum\Peds Volume: | 0.7 mL |
| Container: | Red (no gel) (Green (lithium heparin, no gel), Green (sodium heparin, no gel)) |
| Collection Instructions: | With patient at steady-state, collect sample immediately prior to next dose (trough). Steady-state is achieved after 2.5-11 days of chronic oral dosing. Peak levels usually occur 2-6 hours after oral dose. |
Processing and Shipping
| Specimen Processing: | Centrifuge and aliquot 2 mL, 0.24 mL minimum. Store at room temperature up to 3 days. Alternatively refrigerate or freeze. |
| Shipping Instructions: | Ship at room temperature. |
| Test Performed at or Referral Lab | Lab Sendouts (MedTox) |
| Referral Lab number: | 59 |
Interpretive
| Critical Range: | Imipramine + Metabolite: 500 ng/mL; Desipramine: 500 ng/mL |
| Reference Range: | Total (sum of imipramine and desipramine): 175-300 ng/mL; Desipramine: 100-300 ng/mL |
| Use: | Therapeutic monitoring and assess toxicity. |
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