Imipramine and Desipramine, Serum or Plasma
| Abbrev Code: | IMIPRM | ||
| Order Code: | LAB1225 | Order Name: | Imipramine and Desipramine Level |
| Synonyms: | Tofranil | ||
| Methodology: | Quantitative liquid chromatography/Tandem mass spectrometry | ||
| CPT Codes: | 80335 x2, 80335 x2 | ||
| Test Includes: | Imipramine, Desipramine (metabolite) | ||
| Turnaround Time: | Specimens are sent to the reference laboratory Sun-Sat; testing is performed on Mon, Wed and Fri. Results are reported within 1-5 days. | ||
| Compliance: | ARUP Laboratory Developed Test (LDT): For tests developed and validated by ARUP (previously referred to as Compliance Statement B, C or D). This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes. |
||
Collection Instructions
| Specimen: | Blood |
| Optimal Volume: | 2 mL |
| Minimum\Peds Volume: | 1.2 mL |
| Container: | Red (no gel) Alternate Containers: Purple (EDTA) |
| Collection Instructions: | Timing of specimen collection: Predose (trough) draw - At steady state concentration. |
| Causes for Rejection: | Whole blood. Collected in gel, light blue (citrate), or yellow (SPS or ACD solution) tubes. |
Processing and Shipping
| Specimen Processing: | Centrifuge and separate serum or plasma from cells within 2 hours of collection. Aliquot 1 mL, 0.5 mL minimum. Store in refrigerator. |
| Shipping Instructions: | Ship at refrigerated temperature. |
| Stability: | After separation from cells: 5 days at room temperature; 2 weeks refrigerated; 6 months frozen. |
| Test Performed at or Referral Lab | Lab Sendouts (ARUP) |
| Referral Lab number: | 0090157 |
Interpretive
| Critical Range: | Toxic level: >500 ng/mL
Toxic concentrations may cause anticholinergic effects, drowsiness, and cardiac abnormalities. |
| Therapeutic Range: | Total (sum of imipraine and desipramine): 150-300 ng/mL
Report includes individual values for imipramine, desipramine, and total. |
| Use: | Optimize drug therapy and monitor patient adherence. |
Click HERE to Report test errors or omissions.
*If no email program is associated with this computer, please contact:
systemlabguide@fairview.org for TestID: 1444"